Results 41 to 50 of about 676,033 (247)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Scattering theory of higher order topological phases

SciPost Physics
The surface states of intrinsic higher order topological phases are protected by the spatial symmetries of a finite sample. This property makes the existing scattering theory of topological invariants inapplicable: the scattering geometry is either ...
R. Johanna Zijderveld, Isidora Araya Day, Anton R. Akhmerov
doaj   +1 more source

A model of quantum gravity with emergent spacetime

Journal of High Energy Physics, 2020
We construct a model of quantum gravity in which dimension, topology and geometry of spacetime are dynamical. The microscopic degree of freedom is a real rectangular matrix whose rows label internal flavours, and columns label spatial sites. In the limit
Sung-Sik Lee
doaj   +1 more source

Entanglement spectrum crossings reveal non-Hermitian dynamical topology

Physical Review Research, 2021
The development of non-Hermitian topological band theory has led to observations of novel topological phenomena in effectively classical, driven, and dissipative systems. However, for open quantum many-body systems, the absence of a ground state presents
Sharareh Sayyad, Jinlong Yu, Adolfo G. Grushin, Lukas M. Sieberer   +3 more
doaj   +1 more source

Adaptive feature thresholding for off-line signature verification [PDF]

, 2008
This paper introduces Adaptive Feature Thresholding (AFT) which is a novel method of person-dependent off-line signature verification. AFT enhances how a simple image feature of a signature is converted to a binary feature vector by significantly ...
Larkins, Robert L., Robert Larkins, Michael Mayo, Mayo, Michael   +3 more
core   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Inter-chromosomal contacts demarcate genome topology along a spatial gradient

Nature Communications
Non-homologous chromosomal contacts (NHCCs) between different chromosomes participate considerably in gene and genome regulation. Due to analytical challenges, NHCCs are currently considered as singular, stochastic events, and their extent and ...
Milad Mokhtaridoost, Jordan J. Chalmers, Marzieh Soleimanpoor, Brandon J. McMurray, Daniella F. Lato, Son C. Nguyen, Viktoria Musienko, Joshua O. Nash, Sergio Espeso-Gil, Sameen Ahmed, Kate Delfosse, Jared W. L. Browning, A. Rasim Barutcu, Michael D. Wilson, Thomas Liehr, Adam Shlien, Samin Aref, Eric F. Joyce, Anja Weise, Philipp G. Maass   +19 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

A comprehensive functional analysis of tissue specificity of human gene expression

BMC Biology, 2008
Background In recent years, the maturation of microarray technology has allowed the genome-wide analysis of gene expression patterns to identify tissue-specific and ubiquitously expressed ('housekeeping') genes.
Guryanov Alexey, Brennan Richard J, Rakhmatulin Eugene, Bugrim Andrej, Dosymbekov Damir, Serebriyskaya Tatiana, Shi Weiwei, Sviridov Evgeny, Nikolsky Yuri, Dezső Zoltán, Li Kelly, Blake Julie, Samaha Raymond R, Nikolskaya Tatiana   +13 more
doaj   +1 more source