Results 31 to 40 of about 191,753 (296)

Uninformative polymorphisms bias genome scans for signatures of selection [PDF]

, 2012
With the establishment of high-throughput sequencing technologies and new methods for rapid and extensive single nucleotide (SNP) discovery, marker-based genome scans in search of signatures of divergent selection between populations occupying ...
Daniel Berner, Roesti Marius, Berner Daniel, Marius Roesti, Salzburger Walter, Walter Salzburger, Salzburger, Walter, Berner, Daniel, Roesti, Marius   +8 more
core   +1 more source

YODA: selecting signature oligonucleotides [PDF]

Bioinformatics, 2004
Selecting oligonucleotide probes for use in microarray design, and other applications requiring signature sequences, involves identifying sequences which will bind strongly to their intended target, while binding only weakly (or preferably, not at all) to non-target sequences which may be present in the hybridization reaction.
openaire   +2 more sources

Genome-wide analysis of selection on the malaria parasite Plasmodium falciparum in West African populations of differing infection endemicity. [PDF]

, 2014
Locally varying selection on pathogens may be due to differences in drug pressure, host immunity, transmission opportunities between hosts, or the intensity of between-genotype competition within hosts. Highly recombining populations of the human malaria
Conway, David J, Amambua-Ngwa, A, MacInnis, B, Murray, L, Duffy, Craig W, Duffy, Craig, Mobegi, Victor A, Duffy, CW, Nwakanma, DC, Laman, E, Mobegi, Victor, Laman, Eugene, Kwiatkowski, DP, Conway, David, Kwiatkowski, Dominic, Nwakanma, Davis C, Conway, DJ, Aspeling-Jones, H, Loua, Kovana M, Aspeling-Jones, Harvey, Mobegi, VA, Amambua-Ngwa, Alfred, Murray, Lee, Clark, Taane, Loua, KM, MacInnis, Bronwyn, Clark, Taane G, Clark, TG, Kwiatkowski, Dominic P   +28 more
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Detection of selection signatures in dairy and beef cattle using high-density genomic information [PDF]

, 2015
peer-reviewedBackground Artificial selection for economically important traits in cattle is expected to have left distinctive selection signatures on the genome. Access to high-density genotypes facilitates the accurate identification of
Sinead McParland, Zhao, Fuping, Francis Kearney, Donagh P Berry, Lixin Du, Fuping Zhao, McParland, Sinead, Kearney, Francis, Du, Lixin, Berry, Donagh   +9 more
core   +1 more source

Analysis of selection signatures in the beef cattle genome

Czech Journal of Animal Science, 2019
This study aimed to evaluate the impact of selection on the genome structure of beef cattle through identification of selection signatures reflecting the breeding standard of each breed and to discover potential functional genetic variants to improve ...
Nina Moravčíková, Radovan Kasarda, Luboš Vostrý, Zuzana Krupová, Emil Krupa, Kristína Lehocká, Barbora Olšanská, Anna Trakovická, Rudolf Nádaský, Radoslav Židek, Ľubomír Belej, Jozef Golian   +11 more
doaj   +1 more source

Linkage Disequilibrium as a Signature of Selective Sweeps [PDF]

Genetics, 2004
Abstract The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique distribution of allele frequencies and spatial distribution of polymorphic sites. A composite-likelihood test was previously designed to detect these signatures of a selective sweep, solely on the basis of the spatial distribution and ...
Yuseob, Kim, Rasmus, Nielsen
openaire   +2 more sources

Genome wide signatures of positive selection: The comparison of independent samples and the identification of regions associated to traits [PDF]

, 2009
Background The goal of genome wide analyses of polymorphisms is to achieve a better understanding of the link between genotype and phenotype. Part of that goal is to understand the selective forces that have operated on a population.
Rowan J Bunch, William Barendse, Bunch, Rowan J., Turner, Lex B., Thomas Merle B, Turner Lex B, Bunch Rowan J, Barendse William, Lex B Turner, Merle B Thomas, Barendse, William, Blair E Harrison, Harrison Blair E, Harrison, Blair E., Thomas, Merle B.   +14 more
core   +1 more source

Population genetics: The signature of selection [PDF]

Current Biology, 2001
There is hope that the structure of molecular variation within populations can give evidence for recent adaptive evolution. New work on Drosophila genes that seem to have been subject to adaptive changes illustrates the difficulties in calculating the statistical significance of data trends that seem to show this.
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Complex signatures of natural selection at GYPA [PDF]

Human Genetics, 2018
The human MN blood group antigens are isoforms of glycophorin A (GPA) encoded by the gene, GYPA, and are the most abundant erythrocyte sialoglycoproteins. The distribution of MN antigens has been widely studied in human populations yet the evolutionary and/or demographic factors affecting population variation remain elusive.
Abigail W. Bigham, Kevin Magnaye, Diane M. Dunn, Robert B. Weiss, Michael Bamshad   +4 more
openaire   +2 more sources

Molecular Signatures of Natural Selection [PDF]

Annual Review of Genetics, 2005
There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information.
openaire   +3 more sources