Results 41 to 50 of about 167,728,565 (254)

The repertoire of mutational signatures in human cancer [PDF]

, 2020
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature(1). Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium(2) of the International Cancer
PCAWG Mutational Signatures Workin, López Bigas, Núria, PCAWG Consortium, Alexandrov, Ludmil B.   +3 more
core   +1 more source

A bioinformatics workflow for detecting signatures of selection in genomic data

Frontiers in Genetics, 2014
The detection of signatures of selection is now possible on a genome-wide scale in many plant and animal species, and can be performed in a population-specific manner due to the wealth of per-population genome-wide genotype data that is available.
Murray eCadzow, Murray eCadzow, James eBoocock, James eBoocock, Hoang T Nguyen, Hoang T Nguyen, Phillip eWilcox, Phillip eWilcox, Tony R Merriman, Tony R Merriman, Michael A Black, Michael A Black   +11 more
doaj   +1 more source

Detection and evaluation of selection signatures in sheep [PDF]

Pesquisa Agropecuária Brasileira, 2018
: The recent development of genome-wide single nucleotide polymorphism (SNP) arrays made it possible to carry out several studies with different species.
Tiago do Prado Paim, Patrícia Ianella, Samuel Rezende Paiva, Alexandre Rodrigues Caetano, Concepta Margaret McManus Pimentel   +4 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Cross-population selection signatures in Canchim composite beef cattle.

PLoS ONE, 2022
Analyses of livestock genomes have been used to detect selection signatures, which are genomic regions associated with traits under selection leading to a change in allele frequency.
Igor Nelson Herculano Duarte, Ayrton Fernandes de Oliveira Bessa, Luciana Diniz Rola, Maria Victória Henrique Genuíno, Iasmin Marques Rocha, Cintia Righetti Marcondes, Luciana Correia de Almeida Regitano, Danísio Prado Munari, Donagh Pearse Berry, Marcos Eli Buzanskas   +9 more
doaj   +1 more source

The study of selection signature and its applications on identification of candidate genes using whole genome sequencing data in chicken—a review

Poultry Science, 2023
: Chicken is a major source of protein for the increasing human population and is useful for research purposes. There are almost 1,600 distinct regional breeds of chicken across the globe, among which a large body of genetic and phenotypic variations has
Semiu Folaniyi Bello, Raman Akinyanju Lawal, Adeniyi Charles Adeola, Qinghua Nie   +3 more
doaj   +1 more source

Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba, Shweta Bansal, Tea Reljic, Allyne Montecillo‐Aguelo, Hamidah Alias, Farrah Amaranto, Maria Stella Aquino‐Calingasan, Bambang Ardianto, Eggi Arguni, Sally Blair, Thi Tam Dang, Maria Beatriz Gepte, Samanmalee Gunasekara, Andini Handayani, Miriam Kimpo, Catherine G. Lam, Nawachai Lertvivatpong, Sergio Licona, Ana Loseo, Ratha Mlis, Vivian Moreno Berrio, Nguyen Hoai Anh, Anna Lisa Ong‐Lim, Ha Thu Pham, Krishna Sagar Sharma, Bun Sereyleak, Sally Jane G. Velasco‐Aro, Su Yadana, Ambuj Kumar, Sheena Mukkada   +29 more
wiley   +1 more source

Genomic Analysis Reveals Pleiotropic Alleles at EDN3 and BMP7 Involved in Chicken Comb Color and Egg Production

Frontiers in Genetics, 2019
Artificial selection is often associated with numerous changes in seemingly unrelated phenotypic traits. The genetic mechanisms of correlated phenotypes probably involve pleiotropy or linkage of genes related to such phenotypes.
Xianggui Dong, Junying Li, Yuanyuan Zhang, Deping Han, Guoying Hua, Jiankui Wang, Xuemei Deng, Changxin Wu   +7 more
doaj   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

Radar Signatures of a Passenger Car [PDF]

, 2007
The upcoming new SAR satellites like TerraSAR-X and Radarsat-2 offer high spatial image resolution and dual receive antenna capabilities which open new opportunities for world-wide traffic monitoring applications.
Palubinskas, Gintautas, Runge, Hartmut
core   +1 more source