Results 41 to 50 of about 191,753 (296)

Signature of balancing selection in Arabidopsis [PDF]

Proceedings of the National Academy of Sciences, 2002
Natural selection and genetic linkage cause DNA segments to have genealogical histories resembling those of the selected sites. When a polymorphism maintained by selection is old, it will have an island of enhanced sequence variability surrounding it, which represents a detectable “signature of selection.” We investigate the ...
Dacheng, Tian, Hitoshi, Araki, Eli, Stahl, Joy, Bergelson, Martin, Kreitman   +4 more
openaire   +2 more sources

Positive Selection in East Asians for an EDAR Allele that Enhances NF-κB Activation [PDF]

, 2008
Genome-wide scans for positive selection in humans provide a promising approach to establish links between genetic variants and adaptive phenotypes.
Hughes, David, Myles, Sean, Strotmann, Rainer, Stoneking, M. ; https://orcid.org/, Hughes, D., Pugach, Irina, Hardouin, Emilie, Stajich, Jason E., Jarosław Bryk, Pugach, I., Sean Myles, Hughes, D. ; https://orcid.org/, Jarosław Bryk, Mark Stoneking, Stoneking, Mark, Myles, S., Bryk, J., Bryk, Jarosław, Stoneking, M., Bryk, Jarek, Emilie Hardouin, Hughes, David A., Hardouin, E., Pugach, I. ; https://orcid.org/, Rainer Strotmann, Hardouin, E. ; https://orcid.org/, Myles, S. ; https://orcid.org/, Irina Pugach, David Hughes, Hardouin, E.A., Strotmann, R.   +30 more
core   +1 more source

Genetic architecture and selection of Anhui autochthonous pig population revealed by whole genome resequencing

Frontiers in Genetics, 2022
The genetic resources among pigs in Anhui Province are diverse, but their value and potential have yet to be discovered. To illustrate the genetic diversity and population structure of the Anhui pigs population, we resequenced the genome of 150 pigs from
Wei Zhang, Xiaojin Li, Yao Jiang, Mei Zhou, Linqing Liu, Shiguang Su, Chengliang Xu, Xueting Li, Chonglong Wang   +8 more
doaj   +1 more source

miRNA Signatures in Sera of Patients with Active Pulmonary Tuberculosis. [PDF]

, 2013
Several studies showed that assessing levels of specific circulating microRNAs (miRNAs) is a non-invasive, rapid, and accurate method for diagnosing diseases or detecting alterations in physiological conditions.
Matteelli A., Ilaria C. Valente (488271), Valente I. C., Bosu R., Reither K., Valente, Ilaria C., Grace Mwangoka (488270), Aloi, Francesco, Sotgiu, Giovanni, Mwangoka Grace, Valente, Ilaria C, Delia Goletti, Klaus Reither, Roberta Bosu (488273), Grace Mwangoka, Luigi R Codecasa, Norbert Heinrich, Heinrich Norbert, Giovanni Sotgiu (16787), Ambrosi, Alessandro, Ntinginya, Elias N, Daniela M Cirillo, Bosu, Roberta, Miotto Paolo, Aloi Francesco, Goletti D., Ambrosi Alessandro, Klaus Reither (259897), Ntinginya, Elias N., Paolo Miotto (109897), Mwangoka G., Delia Goletti (78635), Miotto, Paolo, Luigi R. Codecasa (488274), Codecasa, Luigi R., Codecasa, Luigi R, Goletti, Delia, Sotgiu Giovanni, Roberta Bosu, Goletti Delia, Elias N Ntinginya, Norbis, Luca, Luca Norbis, Matteelli Alberto, Matteelli, Alberto, Norbis Luca, Sotgiu G., Valente Ilaria C., Aloi F., Alberto Matteelli, Norbert Heinrich (175590), Ambrosi A., Heinrich N., Cirillo D. M., Alessandro Ambrosi, Francesco Aloi (488276), Norbis L., Codecasa Luigi R., Luca Norbis (488272), Codecasa L. R., Reither, Klaus, Ilaria C Valente, Mwangoka, Grace, Cirillo, Daniela M., Heinrich, Norbert, Cirillo, Daniela M, Elias N. Ntinginya (349100), Reither Klaus, Miotto P., Giovanni Sotgiu, Bosu Roberta, Francesco Aloi, Paolo Miotto, Cirillo Daniela M., Alessandro Ambrosi (94298), Ntinginya Elias N., Alberto Matteelli (488275), Daniela M. Cirillo (109923), Ntinginya E. N.   +78 more
core   +1 more source

The impact of geography and climate on the population structure and local adaptation in a wild bee

Evolutionary Applications, 2023
Deciphering processes that contribute to genetic differentiation and divergent selection of natural populations is useful for evaluating the adaptive potential and resilience of organisms faced with various anthropogenic stressors.
Farida Samad‐zada, Evan P. Kelemen, Sandra M. Rehan   +2 more
doaj   +1 more source

Balancing selection and its effects on sequences in nearby genome regions. [PDF]

, 2006
Our understanding of balancing selection is currently becoming greatly clarified by new sequence data being gathered from genes in which polymorphisms are known to be maintained by selection.
Deborah Charlesworth, Charlesworth Deborah, Charlesworth, Deborah   +2 more
core   +1 more source

Selection for complex traits leaves little or no classic signatures of selection [PDF]

, 2014
BACKGROUND: Selection signatures aim to identify genomic regions underlying recent adaptations in populations. However, the effects of selection in the genome are difficult to distinguish from random processes, such as genetic drift.
Sarah J Saxton, Sunduimijid Bolormaa, Michael E Goddard, Goddard, ME, Kathryn E Kemper, Benjamin J Hayes, Kemper, KE, Bolormaa, S, Saxton, SJ, Hayes, BJ   +9 more
core   +1 more source

A Genome Scan for Selection Signatures in Pigs

PLOS ONE, 2015
Identifying signatures of selection can provide a straightforward insight into the mechanism of artificial selection and further uncover the causal genes related to the phenotypic variation. Based on Illumina Porcine60KSNP chip data, four complementary methods, Long-Range Haplotype (LRH), Tajima's D, Cross Population Extend Haplotype Homozygosity Test (
Yunlong Ma, Julong Wei, Qin Zhang, Lei Chen, Jinyong Wang, Jianfeng Liu, Xiangdong Ding   +6 more
openaire   +4 more sources

Signatures of mutation and selection in the cancer genome [PDF]

Nature, 2010
The cancer genome is moulded by the dual processes of somatic mutation and selection. Homozygous deletions in cancer genomes occur over recessive cancer genes, where they can confer selective growth advantage, and over fragile sites, where they are thought to reflect an increased local rate of DNA breakage.
Bignell, Graham R., Greenman, Chris D., Davies, Helen, Butler, Adam P., Edkins, Sarah, Andrews, Jenny M., Buck, Gemma, Chen, Lina, Beare, David, Latimer, Calli, Widaa, Sara, Hinton, Jonathon, Fahey, Ciara, Fu, Beiyuan, Swamy, Sajani, Dalgliesh, Gillian L., Teh, Bin T., Deloukas, Panos, Yang, Fengtang, Campbell, Peter J., Futreal, P. Andrew, Stratton, Michael R.   +21 more
openaire   +5 more sources

Detection of selection signatures in Piemontese and Marchigiana cattle, two breeds with similar production aptitudes but different selection histories [PDF]

, 2015
Background Domestication and selection are processes that alter the pattern of within- and between-population genetic variability. They can be investigated at the genomic level by tracing the so-called selection signatures.
DIMAURO, Corrado, Sorbolini, S, Valentini, A, MACCIOTTA, Nicolo' Pietro Paolo, Cellesi, M, Marras, G, GASPA, Giustino   +6 more
core   +1 more source