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Selective Sweeps Under Dominance and Inbreeding [PDF]
G3: Genes, Genomes, Genetics, 2020 A major research goal in evolutionary genetics is to uncover loci experiencing positive selection. One approach involves finding ‘selective sweeps’ patterns, which can either be ‘hard sweeps’ formed by de novo mutation, or ‘soft sweeps’ arising from ...
Matthew Hartfield, Thomas Bataillon
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On detecting selective sweeps using single genomes [PDF]
Frontiers in Genetics, 2011 Identifying the genetic basis of human adaptation has remained a central focal point of modern population genetics. One major area of interest has been the use of polymorphism data to detect so-called 'footprints' of selective sweeps - patterns produced ...
Priyanka eSinha +7 more
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diploS/HIC: An Updated Approach to Classifying Selective Sweeps
G3: Genes, Genomes, Genetics, 2018 Identifying selective sweeps in populations that have complex demographic histories remains a difficult problem in population genetics. We previously introduced a supervised machine learning approach, S/HIC, for finding both hard and soft selective ...
Andrew D. Kern, Daniel R. Schrider
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Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation. [PDF]
PLoS Computational Biology, 2013 Selective sweeps are at the core of adaptive evolution. We study how the shape of coalescent trees is affected by recent selective sweeps. To do so we define a coarse-grained measure of tree topology. This measure has appealing analytical properties, its
Haipeng Li, Thomas Wiehe
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eLife, 2022 Analyses of genetic variation in many taxa have established that neutral genetic diversity is shaped by natural selection at linked sites. Whether the mode of selection is primarily the fixation of strongly beneficial alleles (selective sweeps) or ...
David A Murphy +3 more
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Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele. [PDF]
PLoS Genetics, 2015 Methods for detecting the genomic signatures of natural selection have been heavily studied, and they have been successful in identifying many selective sweeps.
Roy Ronen +5 more
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Genome-wide patterns of nucleotide polymorphism in domesticated rice. [PDF]
PLoS Genetics, 2007 Domesticated Asian rice (Oryza sativa) is one of the oldest domesticated crop species in the world, having fed more people than any other plant in human history. We report the patterns of DNA sequence variation in rice and its wild ancestor, O. rufipogon,
Ana L Caicedo +11 more
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G3: Genes, Genomes, Genetics, 2020 The evolution of drug resistance in pathogens such as HIV is an important and widely known example in the field of evolutionary medicine. Here, we focus on a unique data set from the late 1990s with multiple viral sequences from multiple time points in ...
Kadie-Ann Williams, Pleuni Pennings
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The classical hitchhiking model with continuous mutational pressure and purifying selection
Ecology and Evolution, 2021 Detecting selective sweeps driven by strong positive selection and localizing the targets of selection in the genome play a major role in modern population genetics and genomics.
Wolfgang Stephan
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Network models of frequency modulated sweep detection. [PDF]
PLoS ONE, 2014 Frequency modulated (FM) sweeps are common in species-specific vocalizations, including human speech. Auditory neurons selective for the direction and rate of frequency change in FM sweeps are present across species, but the synaptic mechanisms ...
Steven Skorheim +2 more
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