Results 21 to 30 of about 16,978 (246)
Population differentiation as a test for selective sweeps [PDF]
Genome Research, 2010 Selective sweeps can increase genetic differentiation among populations and cause allele frequency spectra to depart from the expectation under neutrality. We present a likelihood method for detecting selective sweeps that involves jointly modeling the multilocus allele frequency differentiation between two populations.
Hua, Chen, Nick, Patterson, David, Reich
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Strong Selective Sweeps on the X Chromosome in the Human-Chimpanzee Ancestor Explain Its Low Divergence. [PDF]
PLoS Genetics, 2015 The human and chimpanzee X chromosomes are less divergent than expected based on autosomal divergence. We study incomplete lineage sorting patterns between humans, chimpanzees and gorillas to show that this low divergence can be entirely explained by ...
Julien Y Dutheil +4 more
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The clarifying role of time series data in the population genetics of HIV.
PLoS Genetics, 2021 HIV can evolve remarkably quickly in response to antiretroviral therapies and the immune system. This evolution stymies treatment effectiveness and prevents the development of an HIV vaccine.
Alison F Feder +2 more
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More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1
eLife, 2016 In the early days of HIV treatment, drug resistance occurred rapidly and predictably in all patients, but under modern treatments, resistance arises slowly, if at all.
Alison F Feder +5 more
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Linkage Disequilibrium as a Signature of Selective Sweeps [PDF]
Genetics, 2004 Abstract The hitchhiking effect of a beneficial mutation, or a selective sweep, generates a unique distribution of allele frequencies and spatial distribution of polymorphic sites. A composite-likelihood test was previously designed to detect these signatures of a selective sweep, solely on the basis of the spatial distribution and ...
Yuseob, Kim, Rasmus, Nielsen
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Private selective sweeps identified from next-generation pool-sequencing reveal convergent pathways under selection in two inbred Schistosoma mansoni strains. [PDF]
PLoS Neglected Tropical Diseases, 2013 BACKGROUND: The trematode flatworms of the genus Schistosoma, the causative agents of schistosomiasis, are among the most prevalent parasites in humans, affecting more than 200 million people worldwide. In this study, we focused on two well-characterized
Julie A J Clément +11 more
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Soft selective sweeps in complex demographic scenarios [PDF]
Genetics, 2014 Recent studies have shown that adaptation from de novo mutation often produces so-called soft selective sweeps, where adaptive mutations of independent mutational origin sweep through the population at the same time. Population genetic theory predicts that soft sweeps should be likely if the product of the population size and the mutation rate towards ...
Wilson, Benjamin A +2 more
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Identifying the favored mutation in a positive selective sweep [PDF]
Nature Methods, 2018 Most approaches that capture signatures of selective sweeps in population genomics data do not identify the specific mutation favored by selection. We present iSAFE (for "integrated selection of allele favored by evolution"), a method that enables researchers to accurately pinpoint the favored mutation in a large region (∼5 Mbp) by using a statistic ...
Ali Akbari +6 more
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Localization of adaptive variants in human genomes using averaged one-dependence estimation
Nature Communications, 2018 Selective sweeps are events in which beneficial mutations spread rapidly through a population. Here, Sugden et al. develop SWIF(r), a probabilistic classification framework for detecting and localizing selective sweeps, and apply it to genomic data from ...
Lauren Alpert Sugden +5 more
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Genetic signatures of evolutionary rescue by a selective sweep [PDF]
Genetics, 2019 Abstract One of the most useful models in population genetics is that of a selective sweep and the consequent hitch-hiking of linked neutral alleles. While variations on this model typically assume constant population size, many instances of strong selection and rapid adaptation in nature may co-occur with complex ...
Osmond, Matthew M., Coop, Graham
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