Results 31 to 40 of about 16,978 (246)
Frontiers in Genetics, 2020 Massive genotyping of single nucleotide polymorphisms (SNP) has opened opportunities for analyzing the way in which selection shapes genomes. Artificial or natural selection usually leaves genomic signatures associated with selective sweeps around the ...
Oscar Aramburu +11 more
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The effects on neutral variability of recurrent selective sweeps and background selection [PDF]
Genetics, 2018 ABSTRACT Levels of variability and rates of adaptive evolution may be affected by hitchhiking, the effect of selection on evolution at linked sites. Hitchhiking can be caused either by selective sweeps or by background selection, involving the spread of new favorable alleles or the elimination of deleterious mutations,
Campos, José Luis, Charlesworth, Brian
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Effects of Linked Selective Sweeps on Demographic Inference and Model Selection [PDF]
Genetics, 2016 Abstract The availability of large-scale population genomic sequence data has resulted in an explosion in efforts to infer the demographic histories of natural populations across a broad range of organisms. As demographic events alter coalescent genealogies, they leave detectable signatures in patterns of genetic variation within and ...
Schrider, Daniel R. +2 more
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Genome-wide selective sweeps and gene-specific sweeps in natural bacterial populations [PDF]
The ISME Journal, 2016 Abstract Multiple models describe the formation and evolution of distinct microbial phylogenetic groups. These evolutionary models make different predictions regarding how adaptive alleles spread through populations and how genetic diversity is maintained.
Matthew L Bendall +18 more
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On the unfounded enthusiasm for soft selective sweeps [PDF]
Nature Communications, 2014 Underlying any understanding of the mode, tempo, and relative importance of the adaptive process in the evolution of natural populations is the notion of whether adaptation is mutation-limited. Two very different population genetic models have recently been proposed in which the rate of adaptation is not strongly limited by the rate ...
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Selective Sweeps in Multilocus Models of Quantitative Traits [PDF]
Genetics, 2012 Abstract We study the trajectory of an allele that affects a polygenic trait selected toward a phenotypic optimum. Furthermore, conditioning on this trajectory we analyze the effect of the selected mutation on linked neutral variation. We examine the well-characterized two-locus two-allele model but we also provide results for diallelic ...
Pavlos, Pavlidis +2 more
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A Selective Sweep across Species Boundaries in Drosophila [PDF]
Molecular Biology and Evolution, 2013 Adaptive mutations that accumulate during species divergence are likely to contribute to reproductive incompatibilities and hinder gene flow; however, there may also be a class of mutations that are generally advantageous and can spread across species boundaries.
Brand, Cara L. +3 more
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S/HIC: Robust Identification of Soft and Hard Sweeps Using Machine Learning.
PLoS Genetics, 2016 Detecting the targets of adaptive natural selection from whole genome sequencing data is a central problem for population genetics. However, to date most methods have shown sub-optimal performance under realistic demographic scenarios. Moreover, over the
Daniel R Schrider, Andrew D Kern
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Frontiers in Plant Science, 2021 Targeted and untargeted selections including domestication and breeding efforts can reduce genetic diversity in breeding germplasm and create selective sweeps in crop genomes.
Aamir Saleem +8 more
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Fixation probability for competing selective sweeps
Electronic Journal of Probability, 2012 We consider a biological population in which a beneficial mutation is undergoing a selective sweep when a second beneficial mutation arises at a linked locus and we investigate the probability that both mutations will eventually fix in the population.
Cuthbertson, Charles +2 more
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