Results 71 to 80 of about 339,158 (270)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Laplacian Spectral Properties of Signed Circular Caterpillars
Theory and Applications of Graphs, 2020 A circular caterpillar of girth $n$ is a graph such that the removal of all pendant vertices yields a cycle $C_n$ of order $n$. A signed graph is a pair $\Gamma=(G, \sigma)$, where $G$ is a simple graph and $\sigma: E(G) \rightarrow \{+1, -1\}$ is the ...
Maurizio Brunetti
doaj +1 more source
Projective-planar signed graphs and tangled signed graphs
Journal of Combinatorial Theory, Series B, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Cubic Time Recognition of Cocircuit Graphs of Uniform Oriented Matroids [PDF]
, 2010 We present an algorithm which takes a graph as input and decides in cubic time if the graph is the cocircuit graph of a uniform oriented matroid. In the affirmative case the algorithm returns the set of signed cocircuits of the oriented matroid.
Felsner, Stefan +4 more
core +2 more sources
European Journal of Combinatorics, 1991 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Discrete Applied Mathematics, 1981 AbstractA signed graph based on F is an ordinary graph F with each edge marked as positive or negative. Such a graph is called balanced if each of its cycles includes an even number of negative edges. Psychologists are sometimes interested in the smallest number d=d(G) such that a signed graph G may be converted into a balanced graph by changing the ...
Akiyama, J. +3 more
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source