Results 81 to 90 of about 52,296 (256)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Discrete Mathematics, 1982 AbstractColoring a signed graph by signed colors, one has a chromatic polynomial with the same enumerative and algebraic properties as for ordinary graphs. New phenomena are the interpretability only of odd arguments and the existence of a second chromatic polynomial counting zero-free colorings. The generalization to voltage graphs is outlined.
openaire +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
On the existence of non-golden signed graphs
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2018 A signed graph is a pair Γ=(G,σ), where G=(V(G), E(G)) is a graph and σ: E(G) → {+1, -1} is the sign function on the edges of G. For a signed graph we consider the least eigenvalue λ(Γ) of the Laplacian matrix defined as L(Γ)=D(G)-A(Γ), where D(G) is the
Maurizio Brunetti
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ON TRANSINVERSE OF MATRICES AND ITS APPLICATIONS [PDF]
Journal of Algebraic SystemsGiven a matrix A with elements from a field of characteristic zero, the transin-verse A# of A is defined as the transpose of the matrix obtained by replacing the non-zero elements of A by their inverses and leaving zeros, if any, unchanged.We discuss the
Koombail Shahul Hameed +1 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
WSGMB: weight signed graph neural network for microbial biomarker identification. [PDF]
Brief Bioinform, 2023 Pan S, Jiang X, Zhang K.
europepmc +1 more source