Results 81 to 90 of about 837,200 (246)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Discrete Applied Mathematics, 2002 A chordally signed graph is defined as a signed chordal graph (each edge is designated as being positive or negative and every induced cycle is a triangle) in which every cycle \(C\) containing an even number of negative edges (positive cycles) has a chord \(e\) such that \(C\cup\{e\}\) forms two positive cycles.
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On the Powers of Signed Graphs
, 2020 A signed graph is an ordered pair $Σ=(G,σ),$ where $G=(V,E)$ is the underlying graph of $Σ$ with a signature function $σ:E\rightarrow \{1,-1\}$. In this article, we define $n^{th}$ power of a signed graph and discuss some properties of these powers of signed graphs.
T V, Shijin, K A, Germina, K, Shahul
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
On equienergetic signed graphs
Discrete Applied Mathematics, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Mushtaq A. Bhat, Shariefuddin Pirzada
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Flow polynomials of a Signed Graph [PDF]
The Electronic Journal of Combinatorics, 2019 For a signed graph $G$ and non-negative integer $d$, it was shown by DeVos et al. that there exists a polynomial $F_d(G,x)$ such that the number of the nowhere-zero $\Gamma$-flows in $G$ equals $F_d(G,x)$ evaluated at $k$ for every Abelian group $\Gamma$ of order $k$ with $\epsilon(\Gamma)=d$, where $\epsilon(\Gamma)$ is the largest integer $d$ for ...
Xiangyu Ren, Jianguo Qian
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Signed Graph Representation Learning
, 2023 This thesis considers the research on signed graph representation learning in different aspects. Signed graphs model complex relations using both positive and negative edges and signed graph neural networks (SGNNs) are powerful tools to analyze signed ...
Zhang, Zeyu
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Discrete Applied Mathematics, 1980 AbstractA class of signed digraphs which arises naturally, in the theory of sign solvable linear systems is introduced. Several results are obtained concerning the structure of such graphs. Also an application is made revealing much of the structure of matrices of sign-solvable systems.
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