Results 61 to 70 of about 34,755 (248)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Generalising the achromatic number to Zaslavsky's colourings of signed graphs
, 2022 The chromatic number, which refers to the minimum number of colours required to colour the vertices of graphs properly, is one of the most central notions of the graph chromatic theory.
Oijid, Nacim +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
On the Laplacian coefficients of signed graphs
, 2015 Let Γ=(G,σ) be a signed graph, where G is its underlying graph and σ its sign function (defined on edges of G). A signed graphΓ′, the subgraph of Γ, is its signed TU-subgraph if the signed graph induced by the vertices ofΓ′consists of trees and/or ...
Simić, Slobodan K. +2 more
core +1 more source
Signed line graphs with least eigenvalue
Discrete Applied Mathematics, 2016 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
BELARDO, Francesco +2 more
openaire +3 more sources
Algorithm to Count the Number of Signed Paths in an Electrical Network via Boolean Formulas
Acta Universitaria, 2012 Este artículo presenta un método práctico para contar los diferentes caminos signados los cuales mantienen una carga eléctrica sobre cada una de las líneas de una red eléctrica. Consideramos que hay sólo una carga (positiva o negativa) en cada nodo de la
Belem Merino +2 more
doaj
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
From finite line graphs to infinite derived signed graphs
Linear Algebra and its Applications, 2014 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources