Results 81 to 90 of about 84,342 (259)
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Visualizing Structural Balance in Signed Networks [PDF]
, 2019 Network visualization has established as a key complement to network analysis since the large variety of existing network layouts are able to graphically highlight different properties of networks. However, signed networks, i.e., networks whose edges are labeled as friendly (positive) or antagonistic (negative), are target of few of such layouts and ...
Galimberti, Edoardo +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
EPJ Data ScienceThe Ego Network Model (ENM) is a model for the structural organisation of relationships, rooted in evolutionary anthropology, that is found ubiquitously in social contexts.
Jack Tacchi +3 more
doaj +1 more source
Static Bipartite Consensus Problems of Heterogeneous Signed Networks
MathematicsThis paper aims to study the distributed control problems of heterogeneous signed networks whose communication topologies are undirected. A distributed control protocol is designed based on neighboring state information.
Yu Ma +4 more
doaj +1 more source
SIGNED PLATT NUMBER IN SIGNED NETWORKS
International Journal of Applied MathematicsIn 1947, J. R. Platt introduced the concept of the Platt number to model the physical properties of alkanes. The Platt number can also be used to analyze other real-world social networks. This paper extends the notion of Platt number to signed Platt number in signed graphs.
openaire +1 more source