Results 61 to 70 of about 84,342 (259)
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Minimum Memory-Based Sign Adjustment in Signed Social Networks
Entropy, 2019 In social networks comprised of positive (P) and negative (N) symmetric relations, individuals (nodes) will, under the stress of structural balance, alter their relations (links or edges) with their neighbours, either from positive to negative or vice ...
Mingze Qi, Hongzhong Deng, Yong Li
doaj +1 more source
Signed Networks: theory, methods, and applications
Signed networks provide a principled framework for representing systems in which interactions are not merely present or absent but qualitatively distinct: friendly or antagonistic, supportive or conflicting, excitatory or inhibitory. This polarity reshapes how we think about structure and dynamics in complex systems: a negative tie is not simply a ...
Diaz-Diaz, Fernando +6 more
openaire +4 more sources
Disagreement in Signed Financial Networks [PDF]
, 2018 We extend the study of rate of convergence to consensus of autonomous agents on an interaction network. In particular, we introduce antagonistic interactions and thus a signed network. This will allow to include the, previously discarded, sign information, in the analysis of disagreement on statistical financial ...
Monica Billio +3 more
openaire +3 more sources
Measuring partial balance in signed networks [PDF]
Journal of Complex Networks, 2017 Peer-reviewed author copy, 31 pages, 6 figures, 5 ...
Samin Aref, Mark C. Wilson
openaire +3 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
SignedLouvain: Louvain for signed networks
CoRRIn this article, we consider the problem of community detection in signed networks. We propose SignedLouvain, an adaptation of the Louvain method to maximise signed modularity, efficiently taking advantage of the structure induced by signed relations. We begin by identifying the inherent limitations of applying the standard Louvain algorithm to signed ...
John N. Pougué-Biyong, Renaud Lambiotte
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source