Results 51 to 60 of about 84,342 (259)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Fairness-Aware Opinion Seeding in Undirected Signed Friedkin–Johnsen Networks

Mathematics
Opinion-maximization methods often optimize an aggregate network response and may therefore distribute target-aligned intervention gains unevenly across groups.
Zenan Lu, Zhongxiang Zhu, Zhenyu Song, Lixing Tan, Chengfei Cai   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Link Prediction in Signed Networks Based on Similarity and Structural Balance Theory

工程科学与技术, 2018
In order to achieve both link prediction and sign prediction in signed networks, a new algorithm PSNBS was proposed on the basis of the similarity and structural balance theory, aiming to address the following two problems, namely, the imbalance between ...
Miaomiao LIU, Jingfeng GUO, Jing CHEN
doaj  

Signed Networks, Triadic Interactions and the Evolution of Cooperation [PDF]

Electronic Proceedings in Theoretical Computer Science, 2013
We outline a model to study the evolution of cooperation in a population of agents playing the prisoner's dilemma in signed networks. We highlight that if only dyadic interactions are taken into account, cooperation never evolves.
Károly Takács, Simone Righi
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Link-Sign Prediction in Dynamic Signed Directed Networks [PDF]

2018 IEEE 4th International Conference on Collaboration and Internet Computing (CIC), 2018
Many real-world applications can be modeled as signed directed graphs wherein the links between nodes can have either positive or negative signs. Social networks can be modeled as signed directed graphs where positive/negative links represent trust/distrust relationships between users.In order to predict user behavior in social networks, several ...
Dang, Quang-Vinh, Ignat, Claudia-Lavinia
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Generalization of clustering coefficients to signed correlation networks.

PLoS ONE, 2014
The recent interest in network analysis applications in personality psychology and psychopathology has put forward new methodological challenges. Personality and psychopathology networks are typically based on correlation matrices and therefore include ...
Giulio Costantini, Marco Perugini
doaj   +1 more source