Results 101 to 110 of about 4,697,954 (305)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2017 Lasègue's sign is an interesting and important clinical sign in medicine for the last 150 years. The Lasègue test is commonly used in the physical examination of patients with low back pain. It is a test for lower lumbosacral nerve root irritation for example, due to disc prolapse.
Surendra Umesh Kamath +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Signs and Beliefs Connected with the Birth of a Son in the Buryat Family
Oriental Studies, 2018 The article is devoted to the study of folk signs and beliefs connected with the birth of a son in the Buryat family in the XIX-XXth centuries.
Vitaly Ochirov
doaj
Nursing OpenAim Being front‐line healthcare professionals is associated with possible severe information anxiety during the COVID‐19 pandemic. Investigating signs of information anxiety is the first and key step of its targeted medical intervention.
Quan Lu +3 more
doaj +1 more source
Scalable ASL sign recognition using model-based machine learning and linguistically annotated corpora [PDF]
, 2018 We report on the high success rates of our new, scalable, computational approach for sign recognition from monocular video, exploiting linguistically annotated ASL datasets with multiple signers.
Dilsizian, Mark +2 more
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Top motor and non-motor complaints in patients with Parkinson's disease
Frontiers in Aging NeuroscienceBackgroundParkinson's disease (PD) is characterized by several motor and non-motor manifestations. These variable neurological complaints have diverse intensity and cause various degrees of disability.Objective methodsWe aimed to assess the top three ...
José Fidel Baizabal-Carvallo +2 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source