Results 11 to 20 of about 85,967 (221)

Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? [PDF]

Mediators of Inflammation, 2017
The immune system has long been thought to be involved in the pathophysiology of complex regional pain syndrome (CRPS). However, not much is known about the role of the immune system and specifically T-cells in the onset and maintenance of this disease ...
Krishna D. Bharwani, Maaike Dirckx, Dirk L. Stronks, Willem A. Dik, Marco W. J. Schreurs, Frank J. P. M. Huygen   +5 more
doaj   +3 more sources

Analysis of Soluble Interleukin‐2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD [PDF]

Annals of Clinical and Translational Neurology
Objective Soluble interleukin‐2 receptor (sIL‐2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) pathogenesis ...
Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann‐Strobl, Friedemann Paul, Patrick Schindler   +8 more
doaj   +3 more sources

Comparison of serum sIL-2R and LDH levels in patients with intravascular large B-cell lymphoma and patients with advanced stage diffuse large B-cell lymphoma [PDF]

J Clin Exp Hematop, 2023
Intravascular large B-cell lymphoma (IVL) is a rare type of lymphoma characterized by tumor growth selectively within the vessels. The 5th edition of the World Health Organization classification defines IVL as a large B-cell lymphoma, the same as diffuse
Yuki Hirami, M. F. Nishimura, T. Urata, Michiko Morimoto, Yukina Maekawa, Tadashi Yoshino, Yoshito Nishimura, Y. Sato   +7 more
semanticscholar   +2 more sources

Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome [PDF]

Arthritis Res Ther, 2022
Background Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune diseases.
Magdalena Keindl, R. Davies, Brith Bergum, J. Brun, D. Hammenfors, R. Jonsson, V. Lyssenko, S. Appel   +7 more
semanticscholar   +2 more sources

Serum soluble interleukin-2 receptor (sIL-2R) is an accurate biomarker for dengue-associated hemophagocytic lymphohistiocytosis syndrome diagnosed by Hscore [PDF]

Infection, 2022
Objective Hemophagocytic lymphohistiocytosis is a potentially fatal complication of severe dengue fever. Here we evaluated the serum soluble IL-2R levels as potential biomarker for identifying HLH in patients with dengue fever.
C. Mahabala, V. K. Koushik, P. Manjrekar, Prashantha Balanthimogru   +3 more
semanticscholar   +2 more sources

Fulminant hepatitis and elevated levels of sIL-2R in thyroid storm [PDF]

Endocrinology, Diabetes & Metabolism Case Reports, 2019
Summary We report the case of a 48-year-old man with thyroid storm associated with fulminant hepatitis and elevated levels of soluble interleukin-2 receptor (sIL-2R). Fatigue, low-grade fever, shortness of breath, and weight loss developed over several months.
Yuri Tanaka, Taisuke Uchida, Hideki Yamaguchi, Yohei Kudo, Tadato Yonekawa, Masamitsu Nakazato   +5 more
openaire   +4 more sources

ACE and sIL-2R correlate with lung function improvement in sarcoidosis during methotrexate therapy. [PDF]

Respiratory Medicine, 2015
In sarcoidosis, the search for disease activity markers that correlate with treatment response is ongoing. The aim of this study was to investigate the pattern of two proposed markers, serum angiotensin-converting enzyme (ACE) and soluble IL-2 receptor (sIL-2R) during methotrexate (MTX) therapy in sarcoidosis patients.We analysed 114 sarcoidosis ...
A. Vorselaars, C. van Moorsel, P. Zanen, H. Ruven, A. Claessen, H. van Velzen-Blad, J. Grutters   +6 more
semanticscholar   +4 more sources

Endothelial dysfunction and proinflammatory state determine severe hematotoxicity and inferior outcome of CAR-T therapy. [PDF]

Hemasphere
Abstract Hematotoxicity and infections are the main drivers of non‐relapse mortality after chimeric antigen receptor (CAR)‐T therapy. Consequently, reliable predictive biomarkers are highly needed to improve risk assessment and optimize patient management.
Scheller L, Zhou X, Loeffler-Wirth H, Kreuz M, Kadel SK, Schimanski S, Schulze H, Ruckdeschel A, Eisele F, Konetzki V, Jornet Culubret M, Merz M, Mersi J, Waldschmidt J, Danhof S, Köhl U, Kortüm KM, Rasche L, Einsele H, Düll J, Topp MS, Hudecek M, Reiche K, Alb M.   +23 more
europepmc   +2 more sources

Prognostic impact of valemetostat in relapsed/refractory adult T-cell leukaemia-lymphoma. [PDF]

Br J Haematol
Summary The prognosis for patients with relapsed/refractory (R/R) adult T‐cell leukaemia‐lymphoma (ATL) remains dismal. Recently, valemetostat, a dual inhibitor for enhancer of zeste homologue (EZH) 1 and 2, was approved in Japan for R/R aggressive ATL. However, there is no real‐world data on the efficacy and prognosis of valemetostat.
Shichijo T, Tatetsu H, Higuchi Y, Miyakawa T, Nosaka K, Nakamura T, Endo S, Yamada A, Wada A, Okamoto Y, Kawakita T, Suzushima H, Matsuoka M, Yasunaga JI.   +13 more
europepmc   +2 more sources

18F-FDG PET, genotype-corrected ACE and sIL-2R in newly diagnosed sarcoidosis [PDF]

European Journal of Nuclear Medicine and Molecular Imaging, 2009
Angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) are serological markers, widely used for determining sarcoidosis activity. (18)F-FDG PET has proven to be a sensitive technique in the imaging of sarcoidosis. The aim of this study was to determine sensitivity of (18)F-FDG PET, genotype-corrected ACE and sIL-2R in active ...
R. Keijsers, F. Verzijlbergen, W. Oyen, J. M. Bosch, H. Ruven, H. Velzen-Blad, J. Grutters   +6 more
semanticscholar   +4 more sources