Engineering miRNA features into siRNAs: Guide-strand bulges are compatible with gene repression
Molecular Therapy: Nucleic Acids, 2022 Synthetic siRNA guide strands are typically designed with perfect complementarity to the passenger strand and the target mRNA. We examined whether siRNAs with intentional guide-strand bulges are functional in vitro and in vivo. Importantly, this was done
Judith Hauptmann +4 more
doaj +1 more source
Digital transformation and post-Covid-19 education in South Africa: a review of literature
South African Computer Journal, 2023 Little thought or speculation was given to the possibilities of digital transformation for basic education until the global Covid-19 pandemic acted as a catalyst for digital transformation in education.
Silence Chomunorwa +2 more
doaj +1 more source
Educator perspectives on the use of technology in schools in previously disadvantaged communities
South African Computer Journal, 2022 Technology plays a crucial role in education and many other sectors of the economy. The national lockdown caused by the Covid-19 pandemic has made apparent the importance of technology in education, with schools that adopted technologies continuing with ...
Silence Chomunorwa +2 more
doaj +1 more source
Less Is More: Novel Hepatocyte-Targeted siRNA Conjugates for Treatment of Liver-Related Disorders
Molecular Therapy: Nucleic Acids, 2020 N-acetyl-galactosamine (GalNAc) conjugation enhances liver specificity for therapeutic oligonucleotides. Here we report on a novel design with improved activity and stability compared with a triantennary design.
Adrien Weingärtner +4 more
doaj +1 more source
Cognitive Repesentations about Experiences of Organizational Silence: A Phenomenological Study in The Islamic Culture and Guidance Office of Chaharmahal and Bakhtiari Province [PDF]
مطالعات منابع انسانی, 2020 Background & Purpose: avoiding from expressing ideas and sharing knowledge and information deprives the organization from a great deal achievements. For this reason, it is necessary to know its causes and consequences of this study was to identify the ...
Abbas Gheadamini +2 more
doaj +1 more source
The Relationship Between Corporate Identity and Organizational Silence [PDF]
مطالعات مدیریت بهبود و تحول, 2017 Organizational silence and corporate identity are challenging concepts for organizations. The the purpose of this research is to investigate the relationship between organizational identity and the organizational silence of Bandar Abbas municipality ...
Hesameddin Kamalzade, Fahime Liaghat
doaj +1 more source
Linguistic and Psycholinguistic Aspects of Silence: A Structural Model of Communication
Дискурс, 2021 Introduction. This work examines the role of silence along the lines of the theoretical considerations suggested by L. Wittgenstein and M. Heidegger. It also focuses on the role of communicative silence in each of the six functions of language in the ...
N. F. Shcherbak, V. I. Potienko
doaj +1 more source
THE CONCEPT OF HUMOR IN LIN YUTANG’S WRITING “MY COUNTRY AND MY PEOPLE” [PDF]
Вісник університету ім. А. Нобеля. Серія Філологічні науки, 2020 The aim of the article is to analyze the concept of humor in lin Yutang’s writing “My Country and My People”. Lin Yutang is a Sino-American writer best known for his research of comic category in the literary and, in general, cultural traditions of ...
Olena A. Mashchenko
doaj +1 more source
Evaluation of Mechanical and Control Systems Serving the Art Museums at Colonial Williamsburg [PDF]
, 2014 This NEH planning grant would be used to evaluate mechanical and control systems serving the DeWitt Wallace Decorative Arts Museum and the Abby Aldrich Rockefeller Folk Art Museum, with the goals of a) developing a plan to replace and upgrade systems and
Patricia Silence, Patricia Silence
core +1 more source
We need to talk about silence: Re-examining silence in International Relations theory [PDF]
, 2015 The critique of silence in International Relations theory has been long-standing and sustained. However, despite the lasting popularity of the term, little effort has been made to unpack the implications of existing definitions and their uses, and of ...
Dingli, Sophia
core +3 more sources