Results 21 to 30 of about 21,659 (247)

Additional prognostic value of stress cardiovascular magnetic resonance for cardiovascular risk stratification after a cryptogenic ischemic stroke

Frontiers in Cardiovascular Medicine, 2022
BackgroundOne-third of ischemic strokes are “cryptogenic” without clearly identified etiology. Although coronary artery disease (CAD) is the main cause of death after stroke, the interest in CAD screening in patients with cryptogenic stroke is still ...
Solenn Toupin, Théo Pezel, Théo Pezel, Francesca Sanguineti, Marine Kinnel, Thomas Hovasse, Thierry Unterseeh, Stéphane Champagne, Philippe Garot, Jérôme Garot   +9 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

FREQUENCY OF POSITIVE EXERCISE TOLERANCE TEST FOR SILENT MYOCARDIAL ISCHEMIA IN ASYMPTOMATIC UNCOMPLICATED TYPE 2 DIABETIC PATIENTS

Pakistan Armed Forces Medical Journal, 2017
Objective: To determine the frequency of positive exercise tolerance test (ETT) for silent myocardial ischemia in asymptomatic uncomplicated type 2 diabetic patients. Study Design: Descriptive- cross sectional study.
Waqas Khalid, Aliya Halim, Amjad khan
doaj   +2 more sources

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Landiolol suppression of electrical storm of torsades de pointes in patients with congenital long-QT syndrome type 2 and myocardial ischemia

Journal of Arrhythmia, 2017
A 76-year-old man who had been diagnosed with long-QT syndrome type 2 had frequent syncopal attacks. The electrocardiogram was monitored, and frequent torsades de pointes (TdP) was detected despite administration of conventional medications: oral ...
Ryota Kitajima, MD, Takeshi Aiba, MD, Tsukasa Kamakura, MD, Kohei Ishibashi, MD, Mitsuru Wada, MD, Yuko Inoue, MD, Koji Miyamoto, MD, Hideo Okamura, MD, Takashi Noda, MD, Satoshi Nagase, MD, Yu Kataoka, MD, Yasuhide Asaumi, MD, Teruo Noguchi, MD, Satoshi Yasuda, MD, Kengo Kusano, MD   +14 more
doaj   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Influence of a complex tratment on serum lipid profile and clinical course of ischemic heart disease inworkers of mining industry [PDF]

Medičnì Perspektivi, 2016
The aim of our study was to investigate the effectiveness of combined therapy with antiplatelet agent clopidogrel (Plagril®, “Dr. Reddy’s Laboratories Limited”, India), and lipid-lowering agent atorvastatin (Atocor®, “Dr.
Fesenko V.I., Роtabashniy V.A.
doaj   +3 more sources

Detection of silent myocardial ischemia in asymptomatic patients with diabetes: results of a randomized trial and meta-analysis assessing the effectiveness of systematic screening

Trials, 2011
Background Most guidelines recommend a systematic screening of asymptomatic high risk patients with diabetes for silent ischemia, but the clinical benefit of this strategy has not been demonstrated compared with the simple control of cardiovascular risk ...
Penfornis Alfred, Rigalleau Vincent, Rodier Michel, Thivolet Charles, Moulin Philippe, Lièvre Michel M, Pradignac Alain, Ovize Michel   +7 more
doaj   +1 more source