Results 191 to 200 of about 595,200 (266)

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Silent myocardial ischemia a critical appraisal

, 1990
International Round Table on Silent Myocardial Ischemia 1989 Tēl-Āvîv, Kellermann, Jan J.   +1 more
core  

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Coronary plaque burden and computed tomography-derived fractional flow reserve are predictors of 5-year mortality in peripheral artery disease patients with no known coronary artery disease. [PDF]

J Vasc Surg Cases Innov Tech
Krievins D, Jegere S, Arko F, Lacis A, Zellans E, Latkovskis G, Kumsars I, Putrins D, Vetra J, Supols E, Zvaigzne L, Tzivian L, Lacis L, Erglis A, Zarins CK.   +14 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

AI‐Enabled Cardiac Rehabilitation for Patients With Heart Failure After Myocardial Infarction: Current Status and Future Prospects

Medicine Advances, EarlyView.
This article illustrates the current dilemmas of myocardial infarction patients after traditional cardiac rehabilitation, as well as the feasibility of using artificial intelligence to optimize and assist with rehabilitation programs such as by integrating mobile apps, wearables, ECGs, medication, vital signs, and assessment data; finally, the AI ...
Xinyuan Huang, Di Chen, Yumin Cai, Zihan Chen, Dongmei Xie, Chaoquan Peng, Yuanlong Li   +6 more
wiley   +1 more source

Wearable Electrocardiogram Technologies for the Early Detection of Acute Coronary Syndromes. [PDF]

JACC Asia
Wang Y, Yu BY, Wong WC, Tam CC, Wong CK, Tse HF.   +5 more
europepmc   +1 more source

Urinary Incontinence and Risk of All‐Cause Mortality: A Systematic Review and Meta‐Analysis of Observational Studies

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Urinary incontinence (UI) is a prevalent condition among adults and imposes a substantial societal burden, yet its association with all‐cause mortality remains uncertain. This study systematically reviewed and quantified the association between UI and mortality risk.
Yanyan Zhou, Liwei Wang, Weijia Sun, Zhong Wang, Kuiqing Shao, Feng Xu, Zhan Gao   +6 more
wiley   +1 more source

[Silent myocardial ischemia].

Wiadomosci lekarskie (Warsaw, Poland : 1960), 1992
M, Krauze-Wielicka, M, Tendera
openaire   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source