Results 61 to 70 of about 1,030,528 (360)

Green synthesis of silver nanoparticles: biomolecule-nanoparticle organizations targeting antimicrobial activity

RSC Advances, 2019
Since discovery of the first antibiotic drug, penicillin, in 1928, a variety of antibiotic and antimicrobial agents have been developed and used for both human therapy and industrial applications. However, excess and uncontrolled use of antibiotic agents
A. Roy, O. Bulut, Sudip Some, Amit Kumar Mandal, M. Yilmaz   +4 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Modeling Tidal Datums and Spatially Varying Uncertainty in the Texas and Western Louisiana Coastal Waters

Journal of Marine Science and Engineering, 2019
Tidal datums are key components in NOAA’s Vertical Datum transformation project (VDatum), which enables effective vertical transformation of the water level between tidal, orthometric, and ellipsoid -based three-dimensional reference systems.
Wei Wu, Edward Myers, Lei Shi, Kurt Hess, Michael Michalski, Stephen White   +5 more
doaj   +1 more source

Regulatory implications of ctDNA in immuno-oncology for solid tumors

Journal for ImmunoTherapy of Cancer, 2023
In the era of precision oncology, use of circulating tumor DNA (ctDNA) is emerging as a minimally invasive approach for the diagnosis and management of patients with cancer and as an enrichment tool in clinical trials.
Harpreet Singh, Richard Pazdur, Paz J Vellanki, Soma Ghosh, Anand Pathak, Michael J Fusco, Erik W Bloomquist, Shenghui Tang, Reena Philip, Julia A Beaver   +9 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

An inventory of Arctic Ocean data in the World Ocean Database [PDF]

Earth System Science Data, 2018
The World Ocean Database (WOD) contains over 1.3 million oceanographic casts (where cast refers to an oceanographic profile or set of profiles collected concurrently at more than one depth between the ocean surface and ocean bottom) collected in the ...
M. M. Zweng, T. P. Boyer, O. K. Baranova, J. R. Reagan, J. R. Reagan, D. Seidov, I. V. Smolyar   +6 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

FTY720 Effects on Inflammation and Liver Damage in a Rat Model of Renal Ischemia-Reperfusion Injury

Mediators of Inflammation, 2019
Objective. Ischemia-reperfusion injury (IRI) produces systemic inflammation with the potential for causing organ failure in tissues peripheral to the initial site of injury.
Anthony D. Foster, Diego Vicente, Nicholas Clark, Crystal Leonhardt, Eric A. Elster, Thomas A. Davis, Matthew J. Bradley   +6 more
doaj   +1 more source

Synthesis of Silver Nanoparticles Mediated by Fungi: A Review

Frontiers in Bioengineering and Biotechnology, 2019
The use of fungi as reducing and stabilizing agents in the biogenic synthesis of silver nanoparticles is attractive due to the production of large quantities of proteins, high yields, easy handling, and low toxicity of the residues.
M. Guilger-Casagrande, R. D. de Lima
semanticscholar   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source