Results 41 to 50 of about 2,016,701 (252)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
New electrodes for silver(II) electrogeneration:comparison between Ti/Pt, Nb/Pt, and Nb/BDD [PDF]
, 2012 Electrochemical processes based on the regeneration of silver (II) are very efficient for the destruction or dissolution of persistent substances. The aim of this work is to assess new anode materials to replace the conventional platinum electrode.
Bertrand, Nathalie +5 more
core +1 more source
Novel Azoles as Antiparasitic Remedies against Brain-Eating Amoebae
Antibiotics, 2020 Balamuthia mandrillaris and Naegleria fowleri are opportunistic protozoan pathogens capable of producing infection of the central nervous system with more than 95% mortality rate.
Ayaz Anwar +8 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Investigating silver coordination to mixed chalcogen ligands [PDF]
, 2012 The work in this project was supported by the Engineering and Physical Sciences Research Council (EPSRC).Six silver(I) coordination complexes have been prepared and structurally characterised. Mixed chalcogen-donor acenaphthene ligands L1–L3 [Acenap(EPh)(
Slawin, Alexandra Martha Zoya +9 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 1995 This pamphlet provides information to help the residents of Little Silver protect local waterways from pollution.Prepared with a grant from the New Jersey Department of Environmental Protection, Office of Environmental Services.Purpose: To help the ...
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Boulton and Fothergill silver. [PDF]
, 1990 PhDThis thesis is about the silver business of Matthew Boulton and John Fothergill at their Soho Manufactory near Birmingham. Their partnership lasted from 1762 until 1782. A rounded discussion of the topic is attempted.
Quickenden, Kenneth
core +4 more sources
InorganicsA family of silver(I) and copper(I) complexes containing carboxylate ligands were prepared from the corresponding carboxylic acids and Ag2O. The compounds were characterized by various spectroscopic methods and X-ray diffraction.
Katharina Hankel née Reinhold +3 more
doaj +1 more source