Results 51 to 60 of about 2,016,701 (252)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Chemical Separation on Silver Nanorods Surface Monitored by TOF-SIMS
Journal of Chemistry, 2017 The article introduces a possible chemical separation of a mixture of two compounds on the metal nanorods surface. A silver nanorods surface has been prepared by controlled electrochemical deposition in anodic alumina oxide (AAO) template.
Ondrej Petruš +8 more
doaj +1 more source
Silver Camphor Imine Complexes: Novel Antibacterial Compounds from Old Medicines
Antibiotics, 2018 The emergence of bacterial resistance to available antimicrobials has prompted the search for novel antibacterial compounds to overcome this public health problem.
Jorge H. Leitão +3 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Phenolic compounds and expression of 4CL genes in silver birch clones and Pt4CL1a lines.
PLoS ONE, 2014 A small multigene family encodes 4-coumarate:CoA ligases (4CLs) catalyzing the CoA ligation of hydroxycinnamic acids, a branch point step directing metabolites to a flavonoid or monolignol pathway.
Suvi Sutela +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Results in ChemistryThis research can potentially impact the silver nanoparticle synthesis field significantly. The study describes the synthesis and tentative mechanism involved in silver nanoparticles with bioactives compounds 1, 2, 3, and 4 (cyclopentane derivative ...
Wangkheirakpam Sujata +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Physical properties and cytotoxicity of silver nanoparticles under different polymeric stabilizers
Heliyon, 2019 At present day, silver nanoparticles are widely used in different fields of human activity. Due to the unique combination of physical and chemical properties, silver nanoparticles have high reactivity and antibacterial activity against microorganisms ...
Roman Verkhovskii +5 more
doaj +1 more source