Results 51 to 60 of about 92,247 (261)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Chemical Separation on Silver Nanorods Surface Monitored by TOF-SIMS

Journal of Chemistry, 2017
The article introduces a possible chemical separation of a mixture of two compounds on the metal nanorods surface. A silver nanorods surface has been prepared by controlled electrochemical deposition in anodic alumina oxide (AAO) template.
Ondrej Petruš, Andrej Oriňak, Renáta Oriňaková, Christian Muhmann, Ján Macko, Radim Hrdý, Jaromír Hubálek, Branislav Erdelyi, Heinrich F. Arlinghaus   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Silver nanoparticles biosynthesis from Ficus pomifera, Strobilanthes flaccidifoliuss, and Crassocephalum crepidioides plant extracts

Results in Chemistry
This research can potentially impact the silver nanoparticle synthesis field significantly. The study describes the synthesis and tentative mechanism involved in silver nanoparticles with bioactives compounds 1, 2, 3, and 4 (cyclopentane derivative ...
Wangkheirakpam Sujata, Warjeet Singh Laitonjam, Purnima Laishram, Nagarajan Sankaranarayanan, Anish Khan, Mohamed Hashem, Hassan Fouad   +6 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Physical properties and cytotoxicity of silver nanoparticles under different polymeric stabilizers

Heliyon, 2019
At present day, silver nanoparticles are widely used in different fields of human activity. Due to the unique combination of physical and chemical properties, silver nanoparticles have high reactivity and antibacterial activity against microorganisms ...
Roman Verkhovskii, Anastasiia Kozlova, Vsevolod Atkin, Roman Kamyshinsky, Tatyana Shulgina, Olga Nechaeva   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Analysis of Extractives in Liquid and Headspace Samples of Silver Fir Using Gas Chromatography Coupled with a Mass Selective Detector

Drvna Industrija
The main objective of the study is to present a chromatographic method that allows rapid and accurate quality control of extractives in liquid and headspace samples of wood and bark of European silver fir (Abies alba Mill.).
Viljem Vek, Ida Poljanšek, Urša Osolnik, Primož Oven   +3 more
doaj   +1 more source