Results 101 to 110 of about 218,831 (262)

The science at HIVR4P 2024: The era of choice in biomedical HIV prevention

Journal of the International AIDS Society, Volume 28, Issue 7, July 2025.
ABSTRACT Introduction HIVR4P 2024, the 5th HIV Research for Prevention Conference, took place in Lima, Peru, 6–10 October 2024. The conference focused on new developments in HIV prevention from basic research to new product development and implementation science.
Beatriz Grinsztejn, Victor Appay, Linda‐Gail Bekker, Chris Beyrer, Deborah Donnell, Jorge Sanchez, Davina Canagasabey, Carolina Coutinho, Yonatan Ganor, Vincent Muturi‐Kioi, Katrina F. Ortblad, Erin Cooney, Gastón Devisich, Paula Ellenberg, Yanina Ghiglione, Kevin K'Orimba, Phionah Kibalama Ssemambo, Natasha Tatiana Ludwig‐Barron, Dieter Kenneth Mielke, Ranajoy Mullick, Michelle Kathini Muthui, Pablo D. Radusky, Emmanuel Sendaula, Syed Raza Haider Tirmizi, Akemi V. Matsuno Sanchez, Julian Vega, Roger Pebody   +26 more
wiley   +1 more source

The Recombinant Maize Ribosome-Inactivating Protein Transiently Reduces Viral Load in SHIV89.6 Infected Chinese Rhesus Macaques

Toxins, 2015
Ribosome inactivating proteins (RIPs) inhibit protein synthesis by depurinating the large ribosomal RNA and some are found to possess anti-human immunodeficiency virus (HIV) activity. Maize ribosome inactivating protein (RIP) has an internal inactivation
Rui-Rui Wang, Ka-Yee Au, Hong-Yi Zheng, Liang-Min Gao, Xuan Zhang, Rong-Hua Luo, Sue Ka-Yee Law, Amanda Nga-Sze Mak, Kam-Bo Wong, Ming-Xu Zhang, Wei Pang, Gao-Hong Zhang, Pang-Chui Shaw, Yong-Tang Zheng   +13 more
doaj   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm, Volume 6, Issue 7, July 2025.
Tumor cells adapt to nutrient‐poor environments by altering metabolism to acquire essential nutrients. They convert glutamine into glutamate and α‐ketoglutarate, supporting mTOR activation and sugar biosynthesis. Disruption of mTORC1 signaling is linked to disease, while glutamine and leucine activation promotes cell growth and inhibits autophagy ...
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
wiley   +1 more source

Ancestral reconstruction supports that loss of Nef-mediated T cell modulation coincided with the emergence of pathogenic lentiviruses

Journal of Virology
Human immunodeficiency virus type 1 (HIV-1) originated following cross-species transmission of simian immunodeficiency virus (SIV) infecting chimpanzees (SIVcpz).
Angelina M. Baldino, Mitchell J. Mumby, Cassandra R. Edgar, Abayomi S. Olabode, Art F. Y. Poon, Jimmy D. Dikeakos   +5 more
doaj   +1 more source

Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication.

PLoS Pathogens, 2016
Within the first three weeks of human immunodeficiency virus (HIV) infection, virus replication peaks in peripheral blood. Despite the critical, causal role of virus replication in determining transmissibility and kinetics of progression to acquired ...
Adam J Ericsen, Michael Lauck, Mariel S Mohns, Sarah R DiNapoli, James P Mutschler, Justin M Greene, Jason T Weinfurter, Gabrielle Lehrer-Brey, Trent M Prall, Samantha M Gieger, Connor R Buechler, Kristin A Crosno, Eric J Peterson, Matthew R Reynolds, Roger W Wiseman, Benjamin J Burwitz, Jacob D Estes, Jonah B Sacha, Thomas C Friedrich, Jason M Brenchley, David H O'Connor   +20 more
doaj   +1 more source

Cortisol and Catecholamine Concentrations Are Affected by Repeated Relocations of Adult Female Rhesus Monkeys (Macaca mulatta)

American Journal of Primatology, Volume 87, Issue 6, June 2025.
Data indicate that, across 3 years, significant elevations in urinary norepinephrine result from housing relocations compared to baseline (Time 1). ABSTRACT In captive primate facilities, relocations—moves, within the facility, from one cage to another—can be common events. On the one hand, relocations are generally regarded as relatively benign events,
John P. Capitanio, Daniel J. Tancredi, Jasmin Zarrabi, Catherine VandeVoort, Cheryl K. Walker   +4 more
wiley   +1 more source

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

Nature Communications, 2017
HIV and simian immunodeficiency virus (SIV) Nef proteins both stimulate the clathrin-mediated endocytosis of CD4 but differ in downmodulation of the immune receptor CD3.
Santiago Manrique, Daniel Sauter, Florian A. Horenkamp, Sebastian Lülf, Hangxing Yu, Dominik Hotter, Kanchan Anand, Frank Kirchhoff, Matthias Geyer   +8 more
doaj   +1 more source

Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120 [PDF]

, 2001
BACKGROUND: Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations
A Boyum, A Robert Neurath, A Trkola, A Trkola, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, AR Neurath, Asim K Debnath, CD Rizzuto, CK Lapham, CM Javan, DR Burton, DR Littman, EA Berger, F Cocchi, G Alkhatib, H Choe, H Deng, J Bilello, JA Este, JC Lee, K Javaherian, KH Manson, L Wu, L Xiao, M Baba, M Baba, M Moulard, M Thali, MA Skinner, MC Peitsch, Nathan Strick, P Greenhead, PD Kwong, RA Anderson, RA Maguire, RF Speck, RJ Shattock, S Harada, S Laal, S Matsushita, S Rusconi, S Shaunak, T Dragic, T Gyotoku, T Kawamura, T Muster, TN Hart, WR Melander, Y Feng, YI Rumyantseva, Yun-Yao Li   +55 more
core   +3 more sources

SIVdrl detection in captive mandrills: are mandrills infected with a third strain of simian immunodeficiency virus? [PDF]

, 2004
A pol-fragment of simian immunodeficiency virus (SIV) that is highly related to SIVdrl-pol from drill monkeys (Mandrillus leucophaeus) was detected in two mandrills (Mandrillus sphinx) from Amsterdam Zoo.
Berkhout, Ben, Gruters, Rob A, Hoyer, Mark J, Osterhaus, Albert DME, van den Burg, Remco, van der Kuyl, Antoinette C   +5 more
core   +7 more sources

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

Genome Medicine, 2018
B cells play a critical role in the immune response by producing antibodies, which display remarkable diversity. Here we describe a bioinformatic pipeline, BALDR (BCR Assignment of Lineage using D e novo Reconstruction) that accurately reconstructs the ...
Amit A. Upadhyay, Robert C. Kauffman, Amber N. Wolabaugh, Alice Cho, Nirav B. Patel, Samantha M. Reiss, Colin Havenar-Daughton, Reem A. Dawoud, Gregory K. Tharp, Iñaki Sanz, Bali Pulendran, Shane Crotty, F. Eun-Hyung Lee, Jens Wrammert, Steven E. Bosinger   +14 more
doaj   +1 more source