Results 111 to 120 of about 218,831 (262)

The Fusion Activity of HIV-1 gp41 Depends on Interhelical Interactions [PDF]

, 2005
Infection by human immunodeficiency virus type I requires the fusogenic activity of gp41, the transmembrane subunit of the viral envelope protein. Crystallographic studies have revealed that fusion-active gp41 is a "trimer-of-hairpins" in which three ...
Chan, David C., Suntoke, Tara R.
core   +1 more source

Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat [PDF]

, 2009
TRIM5[alpha] mediates a potent retroviral restriction phenotype in diverse mammalian species. Here, we identify a TRIM5 transcript in cat cells with a truncated B30.2 capsid binding domain and ablated restrictive function which, remarkably, is conserved ...
Hosie, Margaret J., McEwan, William A., Schaller, Torsten, Towers, Greg J., Willett, Brian J., Ylinen, Laura M.   +5 more
core   +2 more sources

Quantification of Viral RNA and DNA Positive Cells in Tissues From Simian Immunodeficiency Virus/Simian Human Immunodeficiency Virus Infected Controller and Progressor Rhesus Macaques

Frontiers in Microbiology, 2019
Eradication of human immunodeficiency virus 1 (HIV-1) from an infected individual cannot be achieved using current antiretroviral therapy (ART) regimens.
Bapi Pahar, Dot Kuebler, Terri Rasmussen, Xiaolei Wang, Sudesh K. Srivastav, Arpita Das, Ronald S. Veazey   +6 more
doaj   +1 more source

Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription.

PLoS Pathogens, 2020
MHC-I-restricted, virus-specific cytotoxic CD8+ T cells (CTLs) may control human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) replication via the recognition and killing of productively infected CD4+ T cells.
Michelle Zanoni, David Palesch, Claudia Pinacchio, Maura Statzu, Gregory K Tharp, Mirko Paiardini, Ann Chahroudi, Steven E Bosinger, Jack Yoon, Bryan Cox, Guido Silvestri, Deanna A Kulpa   +11 more
doaj   +1 more source

Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review

Pathogens and Immunity, 2016
Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy, due, in part, to the high mutation rate of HIV.
Said A. Hassounah, Thibault Mesplède, Mark A. Wainberg   +2 more
doaj   +1 more source

Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection

Journal of Experimental Medicine, 1997
Clinical isolates of primate immunodeficiency viruses, including human immunodeficiency virus type 1 (HIV-1), enter target cells by sequential binding to CD4 and the chemokine receptor CCR5, a member of the seven-transmembrane receptor family.
M. Farzan, H. Choe, K. Martin, L. Marcon, W. Hofmann, G. Karlsson, Ying Sun, Peter Barrett, N. Marchand, N. Sullivan, N. Gerard, C. Gerard, J. Sodroski   +12 more
semanticscholar   +1 more source

Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIV_smm/mac Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization

mBio, 2019
As a consequence of their independent evolutionary origins in apes and Old World monkeys, human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency viruses of the SIVsmm/mac lineage express phylogenetically and antigenically distinct ...
Benjamin von Bredow, Raiees Andrabi, Michael Grunst, Andres G. Grandea, Khoa Le, Ge Song, Zachary T. Berndsen, Katelyn Porter, Jesper Pallesen, Andrew B. Ward, Dennis R. Burton, David T. Evans   +11 more
doaj   +1 more source

PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. [PDF]

, 2019
Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in ...
Arredondo, Juan, Cortopassi, Gino, Crakes, Katti R, Dandekar, Satya, Datta, Sandipan, Fenton, Anne, Gaulke, Christopher A, Giulivi, Cecilia, Grishina, Irina, Hirao, Lauren A, Marco, Maria L, Napoli, Eleonora, Sankaran-Walters, Sumathi, Santos Rocha, Clarissa   +13 more
core  

Human and simian immunodeficiency viruses: virus-receptor interactions

Trends in Microbiology, 1993
The major cellular receptor for the primate immunodeficiency viruses is the CD4 molecule. As well as mediating virion attachment to the cell surface, CD4 is thought to activate the viral fusion pathway. CD4 is not, however, sufficient for viral entry; other molecules are probably involved, and in certain circumstances these may substitute for CD4 ...
Signoret, N, Poignard, P, Blanc, D, Sattentau, Q   +3 more
openaire   +3 more sources

Downregulation of CCR5 on brain perivascular macrophages in simian immunodeficiency virus-infected rhesus macaques. [PDF]

Brain Behav, 2023
Hattler JB, Irons DL, Luo J, Kim WK.
europepmc   +1 more source