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Pathogenic mechanisms in simian immunodeficiency virus infection
Current Opinion in HIV and AIDS, 2008Recent work in pathogenic simian immunodeficiency (SIV) infection of Asian macaques and in natural, nonpathogenic SIV infections of African nonhuman primate species has demonstrated that persistent activation has profound effects on CD4+ memory T-cell proliferation, differentiation and survival.
Zvi, Grossman, Louis J, Picker
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Simian immunodeficiency virus vectors: Replication and pseudotyping
Journal of Medical Primatology, 1992We studied a single round of replication of Simian immunodeficiency virus (SIV) through the use of a replication defective vector that expresses the hygromycin resistance gene. It was possible to pseudotype SIV particles by complementation with the env gene from a murine amphotropic retrovirus.
T A, Rizvi, A T, Panganiban
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Use of Simian Immunodeficiency Virus for Vaccine Research
Journal of Medical Primatology, 1990Rhesus monkeys were immunized with purified, disrupted, noninfectious simian immunodeficiency virus (SIV) in adjuvant induced SIV neutralizing antibodies. Two of six previously vaccinated macaques were protected against infection when challenged with 200–1,000 animal infectious doses of uncloned, pathogenic SIV and both have remained free of signs of ...
M D, Daniel +8 more
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Mucosal Transmission of Simian Immunodeficiency Virus
1994Although human immunodeficiency virus (HIV) is transmitted primarily by heterosexual contact very little is understood about the biology of heterosexual transmission of HIV. Epidemiological studies indicate that HIV is not efficiently transmitted by sexual contact. In fact many other sexually transmitted diseases (STDs) are more efficiently transmitted.
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Simian Immunodeficiency Virus in People
New England Journal of Medicine, 1994The simian immunodeficiency viruses (SIVs) were initially identified on the basis of antibody cross-reactivity with human immunodeficiency virus type 1 (HIV-1)1. Serum samples from macaque monkeys from Asia with AIDS-like diseases were found to have antibodies that reacted with HIV-1 antigens.
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Histopathological changes in simian immunodeficiency virus infection
The Journal of Pathology, 1990AbstractThe histological lesions were studied in seven rhesus and three cynomolgus monkeys infected with simian immunodeficiency virus for periods ranging from nine weeks to 18 months. Lymphoreticular changes included hyperplasia, follicular involution and depletion, and one animal had amyloidosis of the spleen.
A, Baskerville +8 more
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Simian immunodeficiency virus mac251 infection of astrocytes
Journal of Neurovirology, 2000Human immunodeficiency virus type 1 (HIV-1) infection of astrocytes has been demonstrated in the brains of patients with AIDS dementia complex (ADC) and may play an important role in neuropathological pathways of HIV-related encephalopathy. SIVmac-infected monkeys develop an acquired immunodeficiency syndrome (AIDS) with CNS involvement which is quite ...
G, Guillemin +5 more
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Interstitial pneumonia in simian immunodeficiency virus infection
The Journal of Pathology, 1992AbstractInterstitial pneumonia unrelated to Pneumocystis carinii or other infections was observed histopathologically in 5 of 25 rhesus monkeys infected with simian immunodeficiency virus (SIV). The predominant lesion was lymphocytic infiltration of interalveolar septa and hyperplasia of peribronchial and perivascular lymphoid tissue ...
A, Baskerville +6 more
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Annals of Neurology, 1988
The simian immunodeficiency virus (SIV) is closely related to the human immunodeficiency virus (HIV) in genomic organization and morphology. More important, SIV and HIV are both primate lentiviruses that cause transmissible immunodeficiency and encephalitis, with an apparently increased virulence in the immature host.
L R, Sharer +5 more
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The simian immunodeficiency virus (SIV) is closely related to the human immunodeficiency virus (HIV) in genomic organization and morphology. More important, SIV and HIV are both primate lentiviruses that cause transmissible immunodeficiency and encephalitis, with an apparently increased virulence in the immature host.
L R, Sharer +5 more
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Simian Immunodeficiency Virus Infections
1993African species of nonhuman primates harboring persistent simian immunodeficiency virus (SIV) infections do not develop clinical illness or gross lesions. These species include: African green monkeys infected with SIVAGM, sooty mangabey monkeys infected with SIVSMM(δ), Sykes’ monkeys infected with SIVSYK; mandrills infected with SIVMND, and chimpanzees
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