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Viral zoonosis and human cancer: a perspective. [PDF]
Infect Agent CancerAguayo F.
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The Journal of Immunology, 1962
Summary Simian virus 40 or vacuolating virus infection, in our experience as in that of others, is common in rhesus monkeys and uncommon in Cercopithecus monkeys that reach laboratories in this country. Cynomolgus monkeys resemble the Cercopithecus in this respect.
H M, MEYER +7 more
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Summary Simian virus 40 or vacuolating virus infection, in our experience as in that of others, is common in rhesus monkeys and uncommon in Cercopithecus monkeys that reach laboratories in this country. Cynomolgus monkeys resemble the Cercopithecus in this respect.
H M, MEYER +7 more
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Science, 1980
Small (10 to 150 micrometers) cubic crystals of simian virus 40 have been grown by ammonium sulfate precipitation. Electron micrographs of thin sections from these crystals reveal ordered arrays of virus particles.
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Small (10 to 150 micrometers) cubic crystals of simian virus 40 have been grown by ammonium sulfate precipitation. Electron micrographs of thin sections from these crystals reveal ordered arrays of virus particles.
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Science, 1978
The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5′ end of late messenger RNA.
V B, Reddy +8 more
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The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5′ end of late messenger RNA.
V B, Reddy +8 more
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Simian virus 40 in human cancers
The American Journal of Medicine, 2003Many studies have reported the presence of simian virus 40 (SV40) deoxyribonucleic acid (DNA) or protein in human brain tumors and bone cancers, malignant mesothelioma, and non-Hodgkin's lymphoma. However, the small samples and lack of control groups in some reports have made it difficult to assess their reliability.Studies were included in this ...
Regis A, Vilchez +4 more
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Capsid proteins of simian virus 40
Biochemical and Biophysical Research Communications, 1970Abstract Purified SV40 virions were disrupted by sodium dodecyl sulfate (SDS), β-mercaptoethanol and heat, and the proteins analyzed in polyacrylamide gels in the presence of SDS. Six different polypeptide chains were found. Agregation of proteins was ruled out by treatment with 8 M urea. The major protein had a molecular weight (M.
M, Girard, L, Marty, F, Suarez
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The purification of simian virus 40
Virology, 1964Abstract A procedure for the purification of simian virus 40 is described. This involved treatment of the pellet obtained by centrifugation of the crude virus suspension at 80,000 g with trypsin and deoxycholate, followed by centrifugation in a density gradient.
P H, BLACK, E M, CRAWFORD, L V, CRAWFORD
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Encapsidation of Free Host DNA by Simian Virus 40: A Simian Virus 40 Pseudovirus
Science, 1970Under specified growth conditions, simian virus 40 encapsidated host DNA in a noncircular form free of viral DNA. Two bands of virus particles were present in cesium chloride equilibrium density centrifugation. The host DNA species contained in the upper band was of a lower molecular weight than the DNA present in the mature virus in the lower band.
D M, Trilling, D, Axelrod
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1977
Publisher Summary The essential feature of a virus is its nucleic acid genome, a cluster of genes that brings new information into the cell it infects. Depending on the circumstances of infection, expression of viral genes can lead to multiplication of the virus, and perhaps cell damage or to a stable virus-host cell relationship, in which the cell ...
T J, Kelly, D, Nathans
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Publisher Summary The essential feature of a virus is its nucleic acid genome, a cluster of genes that brings new information into the cell it infects. Depending on the circumstances of infection, expression of viral genes can lead to multiplication of the virus, and perhaps cell damage or to a stable virus-host cell relationship, in which the cell ...
T J, Kelly, D, Nathans
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Association of simian virus 40 T antigen with replicating nucleoprotein complexes of simian virus 40
Journal of Virology, 1980An immunoprecipitation assay was established for simian virus 40 T-antigen-bound nucleoprotein complexes by means of precipitation with sera from hamsters bearing simian virus 40-induced tumors. About 80% of simian virus 40 replicating nucleoprotein complexes in various stages of replication were immunoprecipitated. In contrast, less than 21% of mature
M, Segawa, S, Sugano, N, Yamaguchi
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