Results 171 to 180 of about 1,252,233 (299)

From biogenesis to deep modeling: a holistic review of miRNA-disease prediction computational methods with experimental comparison. [PDF]

Brief Bioinform
Xie S, Law KLE.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Beneath the canopy, beneath the ground: how surface microhabitats shape cave communities. [PDF]

PeerJ
Oliveira MPA, Ferreira RL.
europepmc   +1 more source

A Patent Infringement Analysis Approach Based on Patent Knowledge Graph Driven Fusion of Graph and Image Similarity

Liting Jing, C. Zhou, Di Feng, Yubo Dou, Xiaoyan Fan, Shaofei Jiang   +5 more
openalex   +1 more source

Statistical Long-Range Dependencies and Statistical Self-Similarity in Computer Systems Processing – The Case of Cache Bytes Counter [PDF]

Bartosz Kowal, Dominik Strzałka
openalex   +1 more source

Determining the fluctuation of PM2.5 mass concentration and its applicability to Monin–Obukhov similarity

, 2020
Yan Ren, Hongsheng Zhang, Wei Wei, Xuhui Cai, Yu Song   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Understanding the influence of design-related factors on human-AI teaming in a face matching task. [PDF]

Cogn Res Princ Implic
Kokje E, Lermer E, Donkin C, Gaube S.
europepmc   +1 more source

Compositional Similarity of Urban Green Areas in Southeastern Brazil [PDF]

, 2019
Ronaldo Oliveira dos Santos, Rubiene Neto Soares, Breno Marques da Silva e Silva   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source