Results 231 to 240 of about 1,816,931 (300)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Prevalence and Molecular Epidemiology of Nontyphoidal Salmonella enterica Serovars Enteritidis and Typhimurium in Bushmeat Carcasses Sold in the Centre Region Markets, Cameroon. [PDF]

Microbiologyopen
Dongmo M, Mbuh Nji A, Nsen Bughe R, Fomboh Tah C, Fon Mbacham W, Sado Kamdem SL.   +5 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi-Omics Data. [PDF]

Adv Sci (Weinh)
Ge Y, Zhang F, Liu Y, Jiang C, Gao P, Tan NS, Zhang S, Shen Y, Zhou Q, Zhou X, Wang X, Zhao F, Wang C, Shen X.   +13 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Automated Health Care Thematic Analysis Using a Multiagent Large Language Model: Algorithm Development and Evaluation Study. [PDF]

J Med Internet Res
Xu Q, Amjad N, Giles G, Cumming A, Hermesky D, Wen A, Kwak MJ, Kim Y.   +7 more
europepmc   +1 more source

Virtual Screening for Dual Inhibitors of HDAC6 and MPO: A Multistep Approach Integrating Chemical Space Analysis and Molecular Docking. [PDF]

ACS Omega
de Viveiros BM, Lima CHS, Romeiro NC.
europepmc   +1 more source

Between patterns and predictions: Interpretable latent EEG representations for clinical insights. [PDF]

Neuroimage Clin
Krumm L, Terziev R, Kranz DD, Westover MB, Meisel C.   +4 more
europepmc   +1 more source

Through the Looking Glass: Eye Tracking as a Cognitive Benchmark for Language-Model Semantics and Observer-Specific Semantic Alignment. [PDF]

J Eye Mov Res
Velichkovsky BB, Mukhin IG, Galeeva IR, Sereda-Kalinin PY, Basyul IA, Bessonova YV.   +5 more
europepmc   +1 more source

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies. [PDF]

Rapid Commun Mass Spectrom
Cifuentes P, Garriga A, Fontaine F, Zamora I.   +3 more
europepmc   +1 more source