Results 121 to 130 of about 147,222 (296)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
On accuracy of PDF divergence estimators and their applicability to representative data sampling
, 2011 Generalisation error estimation is an important issue in machine learning. Cross-validation traditionally used for this purpose requires building multiple models and repeating the whole procedure many times in order to produce reliable error estimates ...
Musial, Katarzyna +6 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
An Unsupervised Morphological Criterion for Discriminating Similar Languages
, 2016 In this study conducted on the occasion of the Discriminating between Similar Languages shared task, I introduce an additional decision factor focusing on the token and subtoken level. The motivation behind this submission is to test whether a morphologically-informed criterion can add linguistically relevant information to global categorization and ...
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The important step in the design of a cellular manufacturing (CM) system is to identify the part families and machine groups and consequently to form manufacturing cells.
Hachicha, Wafik +2 more
core
Robust equivalent circuit model parameters identification scheme for State of Charge (SOC) estimation based on maximum correntropy criterion [PDF]
Equivalent circuit model (ECM) parameters identification, which aims to identify the model parameters of ECM accurately is vital for assessing battery status and refining battery management systems (BMS), extensive research has been conducted in this ...
Zhao, Xuezhuan +7 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Combining Analytical and Similarity-Based CBR
, 1988 A technique is presented for combining analytical and similarity-based CBR. Analytical CBR permits transfer from a source problem to a target only if the "analytical criterion" is satisfied, namely, that the justification for the source ...
Paul S. Rosenbloom, Andrew R. Golding
core