Results 41 to 50 of about 7,953 (261)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Extending SPARQL with Similarity Joins
, 2020 We propose techniques that support the efficient computation of multidimensional similarity joins in an RDF/SPARQL setting, where similarity in an RDF graph is measured with respect to a set of attributes selected in the SPARQL query. While similarity joins have been studied in other contexts, RDF graphs present unique challenges.
Sebastián Ferrada +2 more
openaire +2 more sources
Parallel Semantic Trajectory Similarity Join [PDF]
2020 IEEE 36th International Conference on Data Engineering (ICDE), 2020 Matching similar pairs of trajectories, called trajectory similarity join, is a fundamental functionality in spatial data management. We consider the problem of semantic trajectory similarity join (STS-Join). Each semantic trajectory is a sequence of Points-of-interest (POIs) with both location and text information.
Lisi Chen 0001 +4 more
openaire +2 more sources
Exploiting MapReduce-based similarity joins
, 2012 Cloud enabled systems have become a crucial component to efficiently process and analyze massive amounts of data. One of the key data processing and analysis operations is the Similarity Join, which retrieves all data pairs whose distances are smaller ...
Yasin N. Silva, Jason M. Reed
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Similarity joins and clustering for SPARQL
Semantic WebThe SPARQL standard provides operators to retrieve exact matches on data, such as graph patterns, filters and grouping. This work proposes and evaluates two new algebraic operators for SPARQL 1.1 that return similarity-based results instead of exact results. First, a similarity join operator is presented, which brings together similar mappings from two
Sebastián Ferrada +2 more
openaire +1 more source
Proceedings of the VLDB Endowment, 2011 As an essential operation in data cleaning, the similarity join has attracted considerable attention from the database community. In this paper, we study string similarity joins with edit-distance constraints, which find similar string pairs from two large sets of strings whose edit distance is within a given ...
Guoliang Li 0001 +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source