Results 201 to 210 of about 198,995 (264)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Test-Time Training Scaling Laws for Chemical Exploration in Drug Design. [PDF]

J Chem Inf Model
Thomas M, Bou A, De Fabritiis G.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Observer-Independent Assessment of Content Overlap in Mental Health Questionnaires: Large Language Model-Based Study. [PDF]

JMIR AI
Böke A, Hacker H, Chakraborty M, Baumeister-Lingens L, Vöckel J, Koenig J, Vogel DH, Lichtenstein TK, Vogeley K, Kambeitz-Ilankovic L, Kambeitz J.   +10 more
europepmc   +1 more source

BDI-Kit: An AI-powered toolkit for biomedical data harmonization. [PDF]

Patterns (N Y)
Lopez R, Santos A, Koutras C, Freire J.
europepmc   +1 more source

A multi-method integrated weighting framework for biosafety risk assessment of infectious substances. [PDF]

Sci Rep
Wu F, Li C, Bian Y, Li J, Tian J, Li Z.
europepmc   +1 more source

Stability analysis and exploration of multiform soliton solutions for extended fractional NLS model using modified extended direct algebraic method. [PDF]

Sci Rep
Soliman M, Ramadan ME, Alkhatib S, Ahmed HM.   +3 more
europepmc   +1 more source

A strategy combining UPLC fingerprint, chemometrics and quantitative analysis of multi-components by single-marker to control the quality of <i>Carpesium abrotanoides</i> L. [PDF]

RSC Adv
Yang J, Zhang Y, Wang Y, Hu X, Yu J, Fu P, Li S, Yan J.   +7 more
europepmc   +1 more source

Expertise-dependent mental representation in chess: evaluation and comparisons based on structural dimensional analysis-motoric. [PDF]

Front Psychol
Küchelmann T, Velentzas K, Schütz C, Schack T.   +3 more
europepmc   +1 more source