Results 81 to 90 of about 82,785 (291)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

GRAPHICAL ANALYSIS OF LAFFER'S THEORY FOR BENELUX COUNTRIES DURING 1995-2012

open access: yesВісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2015
Concerns about finding a tax burden rate, that generates the largest amount of tax revenues, have attracted the attention of researchers all the time. Law scarcity of public financial resources in relation to public expenditure determines the continuous ...
L. Bunescu
doaj   +1 more source

Size levels for simple closed curves

open access: yesTopology and its Applications, 2002
Let \(X\) be a continuum with hyperspace of nonempty subcontinua \(C(X)\). A size map is a continuous function \(\sigma: C(X)\to [0,+\infty)\) such that \(\sigma(\{x\})=0\) and if \(A\subseteq B\) then \(\sigma(A)\leq \sigma(B)\). This is a generalization of a Whitney map.
openaire   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li   +10 more
wiley   +1 more source

Addendum to: “On partitions of plane sets into simple closed curves. II” [PDF]

open access: yesProceedings of the American Mathematical Society, 1984
This concerns the paper in the same journal Vol. 83, 498-502 (1983; Zbl 0554.54002).
openaire   +2 more sources

Clinical Validation of Plasma p‐217tau in Neurological Diseases

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi   +13 more
wiley   +1 more source

Measuring similarity between curves on 2-manifolds via homotopy area

open access: yesJournal of Computational Geometry, 2019
Measuring the similarity of curves is a fundamental problem arising in many application fields. There has been considerable interest in several such measures, both in Euclidean space and in more general setting such as curves on Riemannian surfaces or ...
Erin Wolf Chambers, Yusu Wang
doaj   +1 more source

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