Results 41 to 50 of about 172,560 (266)

Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models

Scientific Reports, 2021
Estimates of detection and discrimination thresholds are often used to explore broad perceptual similarities between human subjects and animal models.
Pilar Montes-Lourido, Manaswini Kar, Isha Kumbam, Srivatsun Sadagopan   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Emergent Relations after Teaching Textual Responses with Simple Discrimination Procedure in Children

Psicologia, 2010
The repertoire of reading with comprehension has been found during emergent relations tests after teaching with conditional discrimination procedure.
Heloísa Cursi Campos, Nilza Micheletto
doaj  

Tests of Racial Discrimination in a Simple Financial Market: Managers in Major League Baseball

International Journal of Financial Studies, 2018
This study tests for racial discrimination against minority managers in Major League Baseball using financial-market imbalances as it relates to the wagering marketplace for the sport.
Rodney Paul, Andrew Weinbach, Justin Mattingly   +2 more
doaj   +1 more source

Impact of simple substitution methods for missing data on Classical test theory difficulty and discrimination [PDF]

Tutorials in Quantitative Methods for Psychology, 2018
In Classical test theory, difficulty ($p$) and discrimination ($d$) are two item coefficients that are widely used to analyze and validate items in educational testing.
Béland, Sébastien, Jolani, Shahab, Pichette, Fran{\c {c}}ois, Renaud, Jean-Sébastien   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A simple method for algal species discrimination in East China Sea, using multiple satellite imagery

Geoscience Letters, 2022
Satellites can help monitor harmful algal blooms in coastal regions. Methods have been developed using different satellite missions. However, it is necessary to develop a simple and useful method for discriminating harmful algal species that could be ...
Chi Feng, Joji Ishizaka, Shengqiang Wang
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Colorimetric and optical discrimination of halides by a simple chemosensor

RSC Advances, 2015
A simple tripodal copper(ii) complex discriminates halides via a distinct color change for each halide in acetonitrile.
Haque, Syed A, Bolhofner, Robert L, Wong, Bryan M, Hossain, Alamgir   +3 more
openaire   +5 more sources