Results 131 to 140 of about 13,392,009 (311)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Antea Group Archeolgoie 2019/15

, 2020
Antea Group projectnummer 433403 Antea Group heeft in de 17 juli 2018 tot 3 augustus 2018 een archeologisch veldonderzoek (Opgraving, variant archeologische begeleiding) uitgevoerd aan het Achterom te Groningen.
Akkerman, E. (Antea Group), Sibma, T. (Antea Group), Muller, C. (Antea Group)   +2 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Antea Group Archeologie 2017/154

, 2020
Antea projectnummer 419284 In september en oktober 2017 heeft Antea Group een archeologische begeleiding uitgevoerd ter plaate van een gasleidingtracé in de omgeving van Niehove (gemeente Zuidhorn): twee wierdeterreinen bij Frytum, één bij Enuma en een ...
Fens, R. (Antea Group), Sibma, T. (Antea Group)   +1 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Antea Group Archeologie 2016/107

, 2017
Op 22 februari 2016 heeft Antea Group in opdracht van de gemeente Hilversum een archeologische begeleiding uitgevoerd ten behoeve van een kleinschalig crematorium op het terrein.
Colijn, MA J.E. (Antea Group)
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Effects of Bacillus coagulans (GBI-30, 6086) Supplementation on the Fecal Characteristics and Microbiota of Healthy Adult Dogs Subjected to an Abrupt Diet Change

Microorganisms
Studies in humans and livestock have demonstrated Bacillus coagulans GBI-30, 6086 to have probiotic potential, suggesting that it may alleviate gastrointestinal (GI) distress commonly associated with diet change in dogs.
Sofia M. Wilson, Yifei Kang, Jocelyn F. Wren, John F. Menton, Elena Vinay, Mathieu Millette, Melissa R. Kelly, Kelly S. Swanson   +7 more
doaj   +1 more source

Antea Group Archeologie 2019/141

, 2020
Antea Group projectnummer 431766 Antea Group heeft op 9, 10 en 19 april 2018 een archeologisch inventariserend veldonderzoek uitgevoerd op de wierde Groot Maarslag in de gemeente Het Hogeland.
Tuinstra, S.J. (Antea Group), Sibma, T. (Antea Group)   +1 more
core   +1 more source