Results 151 to 160 of about 6,208,817 (342)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Boundedly Simple Groups Have Trivial Bounded Cohomology [PDF]

open access: yesarXiv, 2004
We observe that the singular part of the second bounded cohomology group of boundedly simple groups is trivial.
arxiv  

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

A solvable group isospectral to S(4,3) [PDF]

open access: yesSib. Math. J., 51, N2 (2010), 20-24, 2009
We construct a solvable group G of order 5648590729620 such that the set of element orders of G coincides with that of the simple group S(4,3). This completes the determination of finite simple groups isospectral to solvable groups.
arxiv  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Large subgroups of simple groups

open access: yesJournal of Algebra, 2015
37 ...
Burness, Tim C, Alavi, S. Hassan
openaire   +4 more sources

Torsion units in integral group rings of Conway simple groups [PDF]

open access: yesarXiv, 2010
Using the Luthar--Passi method, we investigate the possible orders and partial augmentations of torsion units of the normalized unit group of integral group rings of Conway simple groups $Co_1$, $Co_2$ and $Co_3$.
arxiv  

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

open access: yesMolecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric   +11 more
wiley   +1 more source

A 3-Local Characterization of the Harada--Norton Sporadic Simple Group [PDF]

open access: yesarXiv, 2012
We provide 3-local characterizations of the Harada--Norton sporadic simple group and its automorphism group. Both groups are examples of groups of parabolic characteristic three and we identify them from the structure of the normalizer of the centre of a Sylow 3-subgroup.
arxiv  

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