Results 31 to 40 of about 643,987 (256)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An In-depth Analysis of Multisensory Reaction Time Disparities between Yogic and Non-Yogic Practitioners

Physical Education Theory and Methodology
Background. Auditory and visual reaction time refers to the duration between the introduction of a sound or light and the onset of a response. It is an important aspect of human behaviour, influencing performance in various activities ranging from daily ...
Tarak Nath Pramanik, Aminur Rahaman, Subrata Pramanick, Prasoon Chowdhuri, Rajib Dutta   +4 more
doaj   +1 more source

Computational models of the Posner simple and choice reaction time tasks

Frontiers in Computational Neuroscience, 2015
The landmark experiments by Posner in the late 1970s have shown thatreaction time (RT) is faster when the stimulus appears in an expectedlocation, as indicated by a cue; since then, the so-called Posnertask has been considered a ``gold standard'' test of
Carolina eFeher Da Silva, Marcus V C Baldo   +1 more
doaj   +1 more source

Timing of expectancy peak in simple reaction time situation

Acta Psychologica, 1974
The present study attempted to determine the moment of the peak expectancy of the imperative stimulus in a simple reaction-time situation with constant foreperiods of 0.25, 0.5, 1, 2 and 4 sec. Four Ss were instructed to indicate the expected moment of the presentation of the imperative stimulus by a key press, i.e., to try to synchronize the key press
R, Näätänen, V, Muranen, A, Merisalo
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Gap effect and reaction time distribution: simple vs choice manual responses

Brazilian Journal of Medical and Biological Research, 1998
It is well known that saccadic reaction times (SRT) are reduced when the target is preceded by the offset of the fixation point (FP) - the gap effect. Some authors have proposed that the FP offset also allows the saccadic system to generate a separate ...
W. Machado-Pinheiro, L.G. Gawryszewski, L.E. Ribeiro-do-Valle   +2 more
doaj   +1 more source

The motor system in simple reaction time experiments

Acta Psychologica, 1974
Abstract In this paper evidence is presented that the variability of the motor system does not play an important role in the variability of simple reaction time. Many studies refer to this fact which, however, seems contradictory to electrophysiological data.
L M, Meijers, E G, Eijkman
openaire   +2 more sources