Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Monstrosity and the Limits of the Intellect: Philosophy as Teratomachy in Descartes
Journal of French and Francophone Philosophy, 2011 For Descartes, nature must be interpreted through a limited number of simple laws used to describe the multiplicity of the real, focusing on the rule and normality rather than on the exception and monstrosity.
Filippo Del Luchesse
doaj +1 more source
A model-based meta-analytic examination of specific reading comprehension deficit: how prevalent is it and does the simple view of reading account for it? [PDF]
Ann Dyslexia, 2021 Wagner RK, Beal B, Zirps FA, Spencer M.
europepmc +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Alfonz Bednár: Sklený vrch, Glass Mount) [PDF]
Slovenska Literatura, 2006 The study about the Bednár´s debut Sklený vrch (The Glass Mount) is focused on an analysis of the stylistic, generic and generally aesthetic fragmentation and ambivalence in ideologically motivated prose work written actually in the post war period.
Zora Prušková
doaj
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Re-examining Husserl’s Non-Conceptualism in the Logical Investigations [PDF]
, 2019 A recent trend in Husserl scholarship takes the Logische Untersuchungen (LU) as advancing an inconsistent and confused view of the non-conceptual content of perceptual experience.
Kidd, Chad
core
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
La mesure de l’analphabétisme en question. Le cas de l’Afrique subsaharienne
Cahiers de la Recherche sur l'Education et les Savoirs, 2013 Sub-Saharan African countries are characterised by a high proportion of illiterate adults and this is not conducive to both economic growth and poverty reduction.
Alain Mingat +2 more
doaj +1 more source
How patients' experiences help institutions to improve care in oncological pathway. [PDF]
To improve services, institutions need to listen the patients voice. The patient experience through the health care pathway can help institutions to point out the problems and to learn to design the organization putting the patient at the center of the ...
Enrico Desideri +3 more
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