Results 111 to 120 of about 1,700,341 (334)

Time as an Empirical Concept in Special Relativity [PDF]

open access: yes, 2019
According to a widespread view, Einstein’s definition of time in his special relativity is founded on the positivist verification principle. The present paper challenges this received outlook.
Slavov, Matias Kimi
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Re-examining Husserl’s Non-Conceptualism in the Logical Investigations [PDF]

open access: yes, 2019
A recent trend in Husserl scholarship takes the Logische Untersuchungen (LU) as advancing an inconsistent and confused view of the non-conceptual content of perceptual experience.
Kidd, Chad
core  

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Monstrosity and the Limits of the Intellect: Philosophy as Teratomachy in Descartes

open access: yesJournal of French and Francophone Philosophy, 2011
For Descartes, nature must be interpreted through a limited number of simple laws used to describe the multiplicity of the real, focusing on the rule and normality rather than on the exception and monstrosity.
Filippo Del Luchesse
doaj   +1 more source

A self-conscious Kurt Vonnegut: an analysis of Cat's Cradle, Slaughterhouse-Five and Breakfast of Champions [PDF]

open access: yes, 2014
The works of Kurt Vonnegut stand as seminal in the American literary canon. Looking at three of his most influential novels, namely Cat's Cradle, Slaughterhouse-Five and Breakfast of Champions, this study aims to better understand the mechanisms which ...
Langdon, Gareth
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Alfonz Bednár: Sklený vrch, Glass Mount) [PDF]

open access: yesSlovenska Literatura, 2006
The study about the Bednár´s debut Sklený vrch (The Glass Mount) is focused on an analysis of the stylistic, generic and generally aesthetic fragmentation and ambivalence in ideologically motivated prose work written actually in the post war period.
Zora Prušková
doaj  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

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