Results 101 to 110 of about 132,453 (282)

Early Literacy Development in Mandarin-Speaking Children: The Role of Phonological Awareness, Rapid Naming and Spoken Language Skills [PDF]

open access: yes, 2012
In Taiwan, many children grow up in a bilingual environment, namely Mandarin and Taiwanese. They learn Zhuyin Fuhao – a semi-syllabic transparent orthography – at the beginning of the first grade before learning traditional Chinese characters.
Yeh, Lili
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

Att orientera sig i text och bild. Skillnader mellan förmodad och faktisk läsning för läsare med dyslexi.

open access: yesActa Didactica Norge, 2013
Artikeln presenterar en fallstudie rörande skillnader mellan faktisk och förmodad läsning. För att belysa fallet har tre unga vuxna med dyslexi undersökts då de läst faktatexter med illustrationer varvid deras ögonrörelser spelats in. Deltagarna har även
Eva Wennås Brante
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Henrietta Dombey Simple view of reading THE SIMPLE VIEW OF READING

open access: yes, 2014
The Simple View of Reading (SVR) is a model of the process of learning to read. As such it is intended as a representation of reality that is simplified in order to allow for better understanding of a complex phenomenon and better management of it.
Henrietta Dombey
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Alfonz Bednár: Sklený vrch, Glass Mount) [PDF]

open access: yesSlovenska Literatura, 2006
The study about the Bednár´s debut Sklený vrch (The Glass Mount) is focused on an analysis of the stylistic, generic and generally aesthetic fragmentation and ambivalence in ideologically motivated prose work written actually in the post war period.
Zora Prušková
doaj  

To get hold of the wrong end of the stick : reasons for poor idiom understanding in children with reading comprehension difficulties. [PDF]

open access: yes, 2008
Purpose: The aim was to identify the source of idiom understanding difficulties in children with specific reading comprehension failure. Method: Two groups (Ns=15) of 9- to 10-year-olds participated. One group had age-appropriate word reading and reading
Cain, Kate, Towse, Andrea S.
core  

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