Results 71 to 80 of about 1,700,341 (334)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Reading profiles in secondary school: concurrent language and cognitive abilities, and retrospective and prospective reading skills

Frontiers in Psychology
IntroductionWe examined the concurrent language and cognitive abilities in a group of Swedish students with different reading profiles in secondary school, and the retrospective (primary school) and prospective (upper-secondary school) reading skills of ...
Christian Waldmann, Maria Levlin
doaj   +1 more source

Graphics of the multitude: reading figure and text in Drawing from the City [PDF]

This essay interrogates the question of reading graphic novels from South Asia by proposing the analysis of Drawing from the City, the visual autobiography of Teju Behan, a contemporary artist from Rajasthan. The essay introduces the text and the author,
Menozzi, F
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Developing young learners’ reading competence in Ethiopia: A critical review of the Ministry of Education’s guidelines for developing supplementary reading materials

Bahir Dar Journal of Education
This study presents a critical review of the official guidelines established in 2016 by the Ethiopian Ministry of Education offering detailed criteria for the development and selection of supplementary reading materials (SRMs) for primary school ...
Samuel Belayneh Kame, Mulugeta Tarekegne Tsegaye, Mona Evelyn Flognfeldt, Margareth Sandvik   +3 more
doaj   +1 more source

Love on the Veldt: Romance and Ideology in Gertrude Page’s ‘A Terror That Saved’ (1912)

NJES: Nordic Journal of English studies, 2017
The following essay offers a close reading of an obscure imperial short story, Gertrude Page’s ‘A Terror That Saved’ (1912), in order to question the assumptions that short fiction about imperial adventure is necessarily masculine, and that short ...
Stephen Donovan
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Shift from High to Liquid Ideals: Making Sense of Journalism and Its Change through a Multidimensional Model

Nordicom Review, 2020
By reading qualitative studies, surveys, organisational histories, and textbooks, one can claim that the ethos of journalists has undergone fundamental changes in recent decades.
Koljonen Kari
doaj   +1 more source

Differences in the Components and Relations of a Multidimensional Model of Reading Comprehension in Low and Average 8- to 11-Year-Old French Readers.

, 2014
International audienceIf the simple view of reading earlier characterised reading comprehension as a product of decoding and linguistic comprehension, research has evolved to a more complex simple view including speed or fluency as a major factor of ...
Bianco, Maryse, Colé, Pascale, Joet, Gwenaelle, Lima, Laurent, Megherbi, Hakima, Nardy, Aurélie   +5 more
core   +1 more source