Results 151 to 160 of about 19,840 (247)

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery

open access: yesProtein Science, Volume 35, Issue 6, June 2026.
Abstract Early‐stage drug discovery relies on the availability of stable protein for reliable biophysical characterization of ligand binding. However, many Plasmodium falciparum proteins are challenging to produce in heterologous systems, which limits their experimental utility.
Marius Amann   +3 more
wiley   +1 more source

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang   +3 more
wiley   +1 more source

Unsupervised Time‐Event Probabilistic Classification Using Large Panels of Time Series

open access: yesStatistical Analysis and Data Mining: An ASA Data Science Journal, Volume 19, Issue 3, June 2026.
ABSTRACT This study presents a framework to perform unsupervised time‐event probabilistic classification using time series data of large cross‐sectional dimension. These datasets often exhibit complexities such as non‐linearities, structural breaks, asynchronicity, missing data, and outliers; which hampers their analysis and modeling.
Máximo Camacho   +2 more
wiley   +1 more source

Mixture‐Based Estimation of Multivariate Data Hypervolume

open access: yesStatistical Analysis and Data Mining: An ASA Data Science Journal, Volume 19, Issue 3, June 2026.
ABSTRACT Estimating the hypervolume occupied by multivariate data is a fundamental problem in statistics and data science, with applications ranging from ecology and machine learning to multi‐objective optimization and Bayesian inference. Traditional approaches rely on geometric approximations, kernel density estimation, or convex‐hull constructions ...
Luca Scrucca
wiley   +1 more source

Position Transmission Control in Tendon–Sheath Mechanisms: A Critical Review and a Promising Solution

open access: yesSmartBot, Volume 2, Issue 2, June 2026.
Tendon‐sheath mechanisms are widely used in various robotic systems for remote position transmission, including aerospace vehicles, flexible rescue robots, dexterous robotic hands, exoskeleton robots, soft wearable devices, industrial robots, and flexible surgical robots.
Jiaqi Li, Qian Gao
wiley   +1 more source

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