Results 131 to 140 of about 19,931 (245)

Advanced Experiment Design Strategies for Drug Development

Advanced Intelligent Discovery, Volume 2, Issue 4, August 2026.
Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang, Anthony Harker, Mohan Edirisinghe, Maryam Parhizkar   +3 more
wiley   +1 more source

A Faithful Discretization of Verbose Directional Transforms. [PDF]

Discrete Comput Geom
Fasy BT, Micka S, Millman DL, Schenfisch A, Williams L.   +4 more
europepmc   +1 more source

Expert Treatment Considerations for Lower Face and Neck Rejuvenation

Dermatological Reviews, Volume 7, Issue 4, August 2026.
ABSTRACT Background The lower face and neck are essential to overall facial harmony and a balanced appearance. Although most nonsurgical treatments have focused on the upper and midface, a variety of minimally invasive options are now available for treating the lower face and neck that target different aesthetic concerns and provide welcome ...
Sabrina Fabi, John Fezza, Jeremy B. Green, Jean Carruthers, Nazanin Ashourian, Elena Dimitrijevic, Steven Yoelin   +6 more
wiley   +1 more source

Non-negative matrix factorization and deconvolution as a dual simplex problem. [PDF]

Genome Biol
Kleverov D, Aladyeva E, Serdyukov A, Artyomov MN.   +3 more
europepmc   +1 more source

Functional and Taxonomic Structuring of Ground‐Dwelling Spider Communities Under the Combined Effects of the Environment and Metal Contamination

Ecology and Evolution, Volume 16, Issue 8, August 2026.
Through a field study along a metal contamination gradient, we propose a combined application of taxonomic and functional approaches to study the impacts of contamination on polyphagous predators, spiders. We have demonstrated a significant impact of metal contamination on spider communities, although it operates among a set of variables (e.g ...
Aliénor Duval, Vincent Laderriere, Margot Jans, Jonathan Bouquerel, Philippe Usseglio‐Polatera, Aurélie Cebron, Florence Maunoury‐Danger   +6 more
wiley   +1 more source

Spatial continuity of neurons explains non-random network architecture. [PDF]

iScience
Reimann MW, Egas Santander D, Kanari L, Barros-Zulaica N.   +3 more
europepmc   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Variable-fidelity EM analysis and simplex-anchored regression surrogates for efficient global optimization of microwave passive circuits. [PDF]

Sci Rep
Pietrenko-Dabrowska A, Koziel S.
europepmc   +1 more source

Virtual Screening of Bacteriocins From Lactic Acid Bacteria Against Monkeypox DNA Polymerase: Sakacin P and Mundticin KS Emerge as Promising Candidates

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
This study employs an in silico virtual screening workflow to evaluate lactic acid bacteria (LAB)‐derived bacteriocins as potential inhibitors of the monkeypox virus DNA polymerase (MPDP). Protein‐peptide docking simulations using the HADDOCK platform revealed that Sakacin P and Mundticin KS possess the highest binding affinities for the MPDP target ...
Melisa Z. Karaman, Karan Goel, Fernando Berton Zanchi, Aykut Ozdarendeli, Somdutt Mujwar, Ahmet E. Yetiman, Ozkan Fidan   +6 more
wiley   +1 more source

Machine learning for microwave optimization using simplex surrogates, dual-resolution computational models and local tuning with sparse sensitivity updates. [PDF]

Sci Rep
Koziel S, Pietrenko-Dabrowska A.
europepmc   +1 more source