Results 111 to 120 of about 19,840 (247)

Bayesian Inference for Multivariate Monotone Densities

Scandinavian Journal of Statistics, EarlyView.
ABSTRACT We consider a nonparametric Bayesian approach to estimation and testing for a multivariate monotone density. Instead of following the conventional Bayesian approach of imposing a prior that satisfies the monotonicity restriction, we place a prior on the step heights via binning and a Dirichlet distribution. The resulting posterior distribution
Kang Wang, Subhashis Ghosal
wiley   +1 more source

SMAA‐Based FITradeoff: An Efficient Framework for Pairwise Elicitation in Multicriteria Decision Analysis

Journal of Multi-Criteria Decision Analysis, Volume 33, Issue 2, August 2026.
ABSTRACT The Flexible and Interactive Tradeoff Elicitation (FITradeoff) method is a Multi‐Attribute Decision‐Making (MADM) approach designed to capture the preferences of a Decision Maker (DM) while minimising cognitive effort. To reduce the frequency of interactions and optimise the preference elicitation process, this paper introduces an innovative ...
Qian Zhao, Elia Balugani, Rita Gamberini, Francesco Lolli   +3 more
wiley   +1 more source

Mixed‐mode membrane chromatography: mechanistic‐modeling‐based optimization and scale‐up of antibody charge variant separation using a novel membrane adsorber

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1407-1419, July 2026.
Abstract BACKGROUND Efficient manufacturing of complex biopharmaceuticals increasingly relies on innovative downstream processing strategies. Membrane chromatography offers a promising alternative to resin‐based systems by enabling high‐throughput separations at elevated flow rates. Typically used in flow‐through mode, its industrial applications range
Jan Hedrich, Rita Steigmiller, Viktor Simaev, Romas Skudas, Michael Schulte, Mathias Hafner, Christian Frech   +6 more
wiley   +1 more source

A Probabilistic Interpretation of the Relative Energy Difference in Hansen Solubility Theory

Macromolecular Theory and Simulations, Volume 35, Issue 4, July 2026.
The relative energy difference (RED) is reformulated as a probabilistic descriptor, replacing the classical sharp solubility boundary with a continuous transition in Hansen space. The approach captures partial compatibility and reveals consistent solubility domains by aligning optimized models with data‐driven decision boundaries.
Otavio Bianchi
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Epigenetic Regulation of Immune Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome

The Prostate, Volume 86, Issue 10, Page 1124-1133, July 2026.
ABSTRACT Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating condition with unclear etiology. Increasing evidence implicates immune dysregulation, yet the molecular mechanisms underlying impaired immune regulation remain poorly defined. This study investigated the role of altered immune responses within
Praveen Thumbikat, Goutham Pattabiraman, Farzaneh Sharifzad, Yongyong Yang, Zhiqiang Liu, Catherine V. Osborn, Stephen F. Murphy, Qi Cao, Anthony J. Schaeffer   +8 more
wiley   +1 more source

Multiechelon Spare Parts Inventory Optimization for Offshore Wind Farm Maintenance: A Decision‐Support Framework for Engineering Managers

Wind Energy, Volume 29, Issue 7, July 2026.
ABSTRACT Offshore wind farm operations depend on timely access to critical spare parts, yet maintenance planning is constrained by long procurement lead times, weather‐limited site access, and geographically distributed storage facilities. This study presents a practically oriented multiechelon spare parts inventory planning framework that supports ...
Md Imran Hasan Tusar, Bhaba Sarker
wiley   +1 more source

Upscaling the Strength Domain of Heterogeneous Cohesive‐Frictional Materials via a General FFT‐Based Limit Analysis Approach

International Journal for Numerical Methods in Engineering, Volume 127, Issue 12, 30 June 2026.
ABSTRACT Limit analysis and yield design provide a well‐defined mathematical framework for upscaling the strength properties of heterogeneous materials. These techniques can be incorporated into an FFT‐based computational micromechanics framework to evaluate the strength of heterogeneous materials, based on images of their microstructure.
Elodie Donval, Matti Schneider
wiley   +1 more source

Semi‐Rational Engineering of Formate Dehydrogenase Reveals Loop Dynamics as a Key Determinant of Thermostability

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Semi‐rational engineering yields a thermostable Bacillus simplex formate dehydrogenase variant (Q125F) with a 25‐fold longer half‐life at 60°C and strong resistance to chemo‐inactivation. Molecular dynamics reveal enhanced π–π interactions stabilizing a flexible loop and enabling efficient NADH regeneration for robust biocatalytic detoxification ...
Rattima Boonkumkrong, Sahachat Soithongcharoen, Pitchayathida Mee‐udorn, Paweenapon Chunthaboon, Somchart Maenpuen, Thanyada Rungrotmongkol, Pratchaya Watthaisong, Ruchanok Tinikul   +7 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source