Results 41 to 50 of about 19,840 (247)
Advanced Experiment Design Strategies for Drug Development
Advanced Intelligent Discovery, EarlyView.Wang et al. analyze 592 drug development studies published between 2020 and 2024 that applied design of experiments methodologies. The review surveys both classical and emerging approaches—including Bayesian optimization and active learning—and identifies a critical gap between advanced experimental strategies and their practical adoption in ...
Fanjin Wang +3 more
wiley +1 more source
Quantum-behaved Particle Swarm Optimization with Nelder-Mead Simplex Search Method [PDF]
Journal of Risk Analysis and Crisis Response (JRACR), 2015 This paper proposes a novel hybrid algorithm based on quantum-behaved particle swarm optimization (QPSO) algorithm and Nelder-Mead (NM) simplex search method for continuous optimization problems, abbreviated as QPSO-NM. This hybrid algorithm is very easy
Weiquan Yao
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley +1 more source
Strong Tracking Spherical Simplex-Radial Cubature Kalman Filter for Maneuvering Target Tracking
Sensors, 2017 Conventional spherical simplex-radial cubature Kalman filter (SSRCKF) for maneuvering target tracking may decline in accuracy and even diverge when a target makes abrupt state changes.
Hua Liu, Wen Wu
doaj +1 more source
Autonomous AI‐Driven Design for Skin Product Formulations
Advanced Intelligent Discovery, EarlyView.This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang +5 more
wiley +1 more source
Croatian Operational Research ReviewParametric programming is one of the notable approaches to expressing the uncertainties encountered in real life. Many studies express the parameters of the objective function and right-hand side parametrically, but only a few include the parametric ...
Gizem Temelcan Ergenecosar +3 more
doaj +1 more source
A Direct Search Algorithm for Global Optimization
Algorithms, 2016 A direct search algorithm is proposed for minimizing an arbitrary real valued function. The algorithm uses a new function transformation and three simplex-based operations.
Enrique Baeyens +2 more
doaj +1 more source
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
An efficient approach to updating simplex multipliers in the simplex algorithm [PDF]
Mathematical Programming, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jian-Feng Hu 0004, Ping-Qi Pan
openaire +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source