Results 31 to 40 of about 13,896,786 (311)

Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs

CPT: Pharmacometrics & Systems Pharmacology, 2021
Tuberculosis (TB) remains a global health problem and there is an ongoing effort to develop more effective therapies and new combination regimes that can reduce duration of treatment.
Helen Humphries, Lisa Almond, Alexander Berg, Iain Gardner, Oliver Hatley, Xian Pan, Ben Small, Mian Zhang, Masoud Jamei, Klaus Romero   +9 more
doaj   +1 more source

Stability analysis of a class of onchocerciasis model

Nantong Daxue xuebao. Ziran kexue ban, 2022
In order to study the model for prevention and control of onchocerciasis, a SEIHUV epidemic model is established, considering the drug treatment of infected persons and people′ s personal protection behavior. The basic theory of differential equations is
LI Longying; LIU Junli
doaj   +1 more source

Biomechanical Stability of Primary and Revision Sacroiliac Joint Fusion Devices: A Cadaveric Study

Global Spine Journal, 2022
Study Design: An in vitro biomechanics study. Objective: To evaluate the efficacy of triangular titanium implants in providing mechanical stabilization to a sacroiliac joint with primary and revision sized implants.
Jake Carbone BS, Isaac Swink MS, Thomas Muzzonigro BS, Daniel Diehl MD, Michael Oh MD, Derek P. Lindsey MS, Scott Yerby PhD, Boyle C. Cheng PhD   +7 more
doaj   +1 more source

A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints [PDF]

, 2015
In an adaptive seamless phase II/III clinical trial interim analysis data are used for treatment selection, enabling resources to be focussed on comparison of more effective treatment(s) with a control.
Friede, Tim, Parsons, Nicholas, Parsons, Nicholas R., Kunz, Cornelia, Todd, Susan, Kunz, Cornelia Ursula, Stallard, Nigel   +6 more
core   +1 more source

A comparison among estimated, simulated and experimental results.

, 2021
A comparison among estimated, simulated and experimental results.
Fakir Sharif Hossain (11547322), Tahmidur Rahman (11547325), Omar Bin Mannan (11547328), Abdullah Al Mamun (6895073), M. Altaf-Ul-Amin (11547331)   +4 more
core   +1 more source

Can We Trust PAICs in Rare Diseases? Methodological Challenges and Limitations

Journal of Market Access & Health Policy
Population-adjusted indirect comparisons (PAICs), including Matching-Adjusted Indirect Comparison and Simulated Treatment Comparison, are increasingly used to inform health technology assessments.
Mikolaj Parkitny, Samuel Aballéa, Piotr Wojciechowski, Mondher Toumi   +3 more
doaj   +1 more source

Advancing unanchored simulated treatment comparisons: A novel implementation and simulation study

Research Synthesis Methods
AbstractPopulation‐adjusted indirect comparisons, developed in the 2010s, enable comparisons between two treatments in different studies by balancing patient characteristics in the case where individual patient‐level data (IPD) are available for only one study.
Shijie Ren, Sa Ren, Nicky J. Welton, Mark Strong   +3 more
openaire   +4 more sources

A comparison of the experimental and simulated data after Lidamycin treatment.

, 2015
A comparison of the experimental and simulated data after Lidamycin treatment.
Le Zhang (88249), Minna Qiao (836556), Xiaobo Zhou (10386), Dan Wu (5969), Michelle Carey (836557)   +4 more
core   +1 more source

Arterial Hypertension and Unusual Ascending Aortic Dilatation in a Neonate With Acute Kidney Injury: Mechanistic Computer Modeling

Frontiers in Physiology, 2019
BackgroundNeonatal asphyxia caused kidney injury and severe hypertension in a newborn. An unusually dilatated ascending aorta developed. Dialysis and pharmacological treatment led to partial recovery of the ascending aortic diameters. It was hypothesized
Luis Altamirano-Diaz, Luis Altamirano-Diaz, Luis Altamirano-Diaz, Andrea D. Kassay, Baran Serajelahi, Christopher W. McIntyre, Christopher W. McIntyre, Christopher W. McIntyre, Guido Filler, Guido Filler, Guido Filler, Guido Filler, Sanjay R. Kharche, Sanjay R. Kharche, Sanjay R. Kharche   +14 more
doaj   +1 more source

Pharmacoeconomic analysis of first-choice antimicrobial drugs prescribed for outpatient treatment of non-severe community-acquired pneumonia

Фармакоэкономика, 2021
The study aimed to perform a pharmacoeconomic analysis of antimicrobial drugs (AMDs) prescribed for the treatment of community-acquired pneumonia (CAP) in outpatient conditions.Materials and methods.
V. G. Deriushkin, A. P. Ternavskii, S. V. Gatsura   +2 more
doaj   +1 more source