Results 41 to 50 of about 250,324 (265)

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

A multi-objective simulation-optimization model constrained by the potential seawater intrusion

Shui kexue jinzhan, 2015
A linked simulation-optimization model(SWT-NPTSGA) using the niched Pareto tabu search combined with a genetic algorithm(NPTSGA),is developed for deriving multiple objective management strategies for coastal aquifers,involving seawater intrusion control ...
YANG Yun, WU Jianfeng, LIN Jin, WU Jichun, WANG Jinguo   +4 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

A dual-inexact fuzzy stochastic model for water resources management and non-point source pollution mitigation under multiple uncertainties [PDF]

Hydrology and Earth System Sciences, 2014
In this research, a dual-inexact fuzzy stochastic programming (DIFSP) method was developed for supporting the planning of water and farmland use management system considering the non-point source pollution mitigation under uncertainty.
C. Dong, Q. Tan, G.-H. Huang, Y.-P. Cai
doaj   +1 more source

Testing strategies for simulation optimization [PDF]

Proceedings of the 19th conference on Winter simulation - WSC '87, 1987
There is increasing interest in science and industry in the optimization of computer simulation models. Often these models are not Monte-Carlo simulations, but consist of systems of differential equations, or other mathematical models. These models can present special problems to numerical optimization methods. First, derivatives are often unavailable.
openaire   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Development of Simulation-Optimization Model for Eutrophication Management in Surface Water Reservoirs by System Dynamic Approach [PDF]

مهندسی منابع آب, 2020
In this research, for the first time, a simulation-optimization system dynamic-based model with Anylogic software for reservoir eutrophication management is presented.
fariborz masoumi
doaj  

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Efficient prediction of aerodynamic forces in rarefied flow using convolutional neural network based multi-process method

Machine Learning: Science and Technology
The direct simulation Monte Carlo (DSMC) is a widely used approach for studying aerodynamics effects of rarefied flows, but it is highly time-consuming and may exhibit statistical fluctuations.
Haifeng Huang, Guobiao Cai, Chuanfeng Wei, Baiyi Zhang, Xiang Cui, Yongjia Zhao, Huiyan Weng, Weizong Wang, Lihui Liu, Bijiao He   +9 more
doaj   +1 more source