Results 61 to 70 of about 3,622,113 (279)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Elements of a Theory of Simulation
, 1995 Unlike computation or the numerical analysis of differential equations, simulation does not have a well established conceptual and mathematical foundation. Simulation is an arguable unique union of modeling and computation.
Barrett, Christopher, Rasmussen, Steen
core +3 more sources
Regression Analysis for Simulation Practitioners [PDF]
Journal of the Operational Research Society, 1981 Some simple extensions of elementary regression analysis useful for analyzing simulation experiments are given. In simulation variance estimates (standard errors) are usually available but often do not satisfy the assumption of constant variance which underlies elementary regression analysis.
openaire +3 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Measuring Decentrality in Blockchain Based Systems
IEEE Access, 2020 Blockchain promises to provide a distributed and decentralized means of trust among untrusted users. However, in recent years, a shift from decentrality to centrality has been observed in the most accepted Blockchain system, i.e., Bitcoin. This shift has
Sarada Prasad Gochhayat +5 more
doaj +1 more source
Analysis, Simulation and Control of a New Measles Epidemic Model [PDF]
, 2019 In this paper the problem of modeling and controlling the measles epidemic spread is faced. A new model is proposed and analysed; besides the categories usually considered in measles modeling, the susceptible, the exposed, the infected, the removed and,
DI GIAMBERARDINO, Paolo +1 more
core +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
LandOptimizing agricultural carbon compensation zoning is crucial for establishing robust mechanisms in agricultural carbon compensation management, with significant implications for achieving national “dual carbon” strategic objectives. This study employs K-
Zhengkun Yang +3 more
doaj +1 more source
Object-Oriented and Deep-Learning-Based High-Resolution Mapping from Large Remote Sensing Imagery
Canadian Journal of Remote Sensing, 2021 Land use and land cover (LULC) mapping is a basic research topic in geography. In deep-learning (DL)-based LULC mapping, there are primarily the following issues: training and testing samples for DL are typically annotated by indoor visual interpretation
Yijin Wu +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source