Results 121 to 130 of about 7,798,024 (252)

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

Cloud Computing for Simulation in Manufacturing and Engineering: Introducing the CloudSME Simulation Platform

, 2014
There are many benefits of implementing simulation software on a Cloud. These include the use of scalable, on-demand access to resources that can be used to speed up simulation and the development of composable Modeling & Simulation services (Modeling ...
Kiss, T., Terstyanszky, G., Taylor, S.J.E., Fantini, N., Kacsuk, P.   +4 more
core  

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Research on Scenario-driven Virtual Simulation Test Method for Autonomous Escort Function of Habor Tugs

: In order to comprehensively construct the test scenarios and verify the reliability of the tugboat autonomous companionway function, a scenario-driven virtual simulation test method for the tugboat autonomous companionway function is proposed. Based on
Xu, Chengqi, Li, Shijie, Dong, Zhilin, Li, Jialin, Liu, Jialun   +4 more
core   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Simulation of polymer melts using Radial Basis Function and Brownian configuration field method [PDF]

Polymer melts are viscoelastic fluids and extremely complex fluids due to the existence of very high density of polymer molecules. Polymer melt rheology aims to understand and quantify the viscous and elastic properties of a polymer.
Tran, Canh-Dung, Nguyen, Hung Quoc
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source

Digital Transformation in Materials Science: A User Journey of Nanoindentation, Image Analysis and Simulations

Data Science Journal
A robust digital infrastructure, built upon overarching frameworks and software tools, is essential for the ongoing digital transformation in materials science and engineering. This user journey demonstrates the seamless integration of distinct technical
Hanna Tsybenko, Sarath Menon, Fei Chen, Abril Azocar Guzman, Katharina Grünwald, Steffen Brinckmann, Tilmann Hickel, Tim Dahmen, Volker Hofmann, Stefan Sandfeld, Ruth Schwaiger   +10 more
doaj   +1 more source

Study of Setting up Simulation Platform of Self-adaptive Flight Control System with Self-repair Function

, 2020
: The frame and characteristic of self-adaptive flight control system with self-repair function for aircraft with thrust vector were studied. RHO optimal algorithm was used to realize online controller design.
Hao, Long, Song, Shujie
core