Results 101 to 110 of about 729,727 (315)

Optimization in a Simulation Setting: Use of Function Approximation in Debt Strategy Analysis [PDF]

The stochastic simulation model suggested by Bolder (2003) for the analysis of the federal government's debt-management strategy provides a wide variety of useful information.
Tiago Rubin, David Jamieson Bolder
core  

Simulation as a Research Translation Technique

, 2019
In the clinical setting, simulation is emerging as an important educational technology for learning about contemporary clinical care. The aim of this case study was to illustrate the feasibility of simulation as a research translation mechanism ...
Myers, S, Todd, JA, Grealish, Laurie, Grealish, L, Scott, C, Krug, M, Todd, Jo-Anne   +6 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Performance Comparison of the Digital Neuromorphic Hardware SpiNNaker and the Neural Network Simulation Software NEST for a Full-Scale Cortical Microcircuit Model

Frontiers in Neuroscience, 2018
The digital neuromorphic hardware SpiNNaker has been developed with the aim of enabling large-scale neural network simulations in real time and with low power consumption.
Sacha J. van Albada, Andrew G. Rowley, Johanna Senk, Michael Hopkins, Maximilian Schmidt, Maximilian Schmidt, Alan B. Stokes, David R. Lester, Markus Diesmann, Markus Diesmann, Markus Diesmann, Steve B. Furber   +11 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Using simulation to estimate critical paths and survival functions in aircraft turnaround processes

, 2017
In the context of aircraft turnaround processes, this paper illustrates how simulation can be used not only to analyze critical activities and paths, but also to generate the associated survival functions ' thus providing the probabilities that the ...
Juan Pérez, Ángel Alejandro, Fonseca Casas, Pau, Guimarans Serrano, Daniel, San Antonio, Andrés, Calvet Liñan, Laura   +4 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

VIOLA—A Multi-Purpose and Web-Based Visualization Tool for Neuronal-Network Simulation Output

Frontiers in Neuroinformatics, 2018
Neuronal network models and corresponding computer simulations are invaluable tools to aid the interpretation of the relationship between neuron properties, connectivity, and measured activity in cortical tissue.
Johanna Senk, Corto Carde, Corto Carde, Corto Carde, Espen Hagen, Espen Hagen, Torsten W. Kuhlen, Torsten W. Kuhlen, Markus Diesmann, Markus Diesmann, Markus Diesmann, Benjamin Weyers, Benjamin Weyers   +12 more
doaj   +1 more source

Optimisation of a complex simulation model

, 2003
In this paper we describe techniques utilised in the development of a scheme for identifying the regions in an 8-dimensional parameter space that gave optimal (or near-optimal) performance in a computational simulation of a real-world system.
Sherlock, R, Liu, D, Post, E, Kulasiri, Don   +3 more
core