Results 81 to 90 of about 729,727 (315)

A Closed-Loop Toolchain for Neural Network Simulations of Learning Autonomous Agents

Frontiers in Computational Neuroscience, 2019
Neural network simulation is an important tool for generating and evaluating hypotheses on the structure, dynamics, and function of neural circuits. For scientific questions addressing organisms operating autonomously in their environments, in particular
Jakob Jordan, Jakob Jordan, Philipp Weidel, Philipp Weidel, Philipp Weidel, Abigail Morrison, Abigail Morrison   +6 more
doaj   +1 more source

Efficient Communication in Distributed Simulations of Spiking Neuronal Networks With Gap Junctions

Frontiers in Neuroinformatics, 2020
Investigating the dynamics and function of large-scale spiking neuronal networks with realistic numbers of synapses is made possible today by state-of-the-art simulation code that scales to the largest contemporary supercomputers.
Jakob Jordan, Jakob Jordan, Jakob Jordan, Jakob Jordan, Moritz Helias, Moritz Helias, Moritz Helias, Moritz Helias, Markus Diesmann, Markus Diesmann, Markus Diesmann, Markus Diesmann, Markus Diesmann, Susanne Kunkel   +13 more
doaj   +1 more source

Characteristic function estimation of Ornstein-Uhlenbeck-based stochastic volatility models. [PDF]

Continuous-time stochastic volatility models are becoming increasingly popular in finance because of their flexibility in accommodating most stylized facts of financial time series.
Emanuele Taufer, Nikolai Leonenko, Marco Bee   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Interpolative Rus-Reich-Ćirić Type Contractions via Simulation Functions

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2019
In this paper, we introduce the notion of interpolative Rus-Reich-Ćirić type 𝒵- contractions in the setting of complete metric space. We also consider some immediate consequences of our main results.
Karapınar Erdal, Agarwal Ravi P.
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Biomolecular interactions modulate macromolecular structure and dynamics in atomistic model of a bacterial cytoplasm

eLife, 2016
Biological macromolecules function in highly crowded cellular environments. The structure and dynamics of proteins and nucleic acids are well characterized in vitro, but in vivo crowding effects remain unclear.
Isseki Yu, Takaharu Mori, Tadashi Ando, Ryuhei Harada, Jaewoon Jung, Yuji Sugita, Michael Feig   +6 more
doaj   +1 more source

The Exponential Logarithm Function As An Algorithm For Business Simulation

, 1987
" Business simulation designers have taken two distinct approaches to defining the functional relationships necessary to make the simulation as realistic as possible. The first approach is the generalized multiplicative model.
Decker, Ronald, Adler, Thomas, LaBarre, James   +2 more
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Root growth model: a novel approach to numerical function optimization and simulation of plant root system

, 2014
This paper presents a general optimization model gleaned ideas from root growth behaviors in the soil. The purpose of the study is to investigate a novel biologically inspired methodology for complex system modeling and computation, particularly for ...
Zhu YL(朱云龙), Chen HN(陈瀚宁), Zhang H(张浩)   +2 more
core   +1 more source