Results 61 to 70 of about 7,798,024 (252)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Correlation functions and computer simulations

Nuclear Physics B, 1981
If the equilibrium properties of a statistical system are obtained by solving numerically the associated Langevin equation describing the approach to equilibrium, the connected correlation functions can be computed directly with small effort and high precision.
openaire   +1 more source

Fixed point theorems for simulation functions in $\mbox{b}$-metric spaces via the $wt$-distance

Applied General Topology, 2017
The purpose of this article is to prove some fixed point theorems for simulation functions  in complete b-metric   spaces with partially ordered  by using wt-distance which introduced by   Hussain et al.
Chirasak Mongkolkeha, Yeol Je Cho, Poom Kumam   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Exponential Logarithm Function As An Algorithm For Business Simulation

, 1987
" Business simulation designers have taken two distinct approaches to defining the functional relationships necessary to make the simulation as realistic as possible. The first approach is the generalized multiplicative model.
Decker, Ronald, Adler, Thomas, LaBarre, James   +2 more
core   +1 more source

Proximal $\mathfrak{Z}$-Condensing Operators via Simulation Functions and Applications

Computation
In this paper, we introduce and study proximal Z-condensing operators in strictly convex Banach spaces by combining simulation functions with measures of noncompactness.
Moosa Gabeleh, Maggie Aphane
doaj   +1 more source

Best Proximitiy Point Results for Geraghty Type ?-Proximal Contractions with an Application

Axioms, 2019
In this study, we establish the existence and uniqueness theorems of the best proximity points for Geraghty type ?-proximal contractions defined on a complete metric space.
Hüseyin Işık, Hassen Aydi, Nabil Mlaiki, Stojan Radenović   +3 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source