Results 81 to 90 of about 15,260 (213)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Association between insufficient level of physical activity and multiple health risk behaviors in adolescents

open access: yesMotriz: Revista de Educacao Fisica, 2019
Aim: To verify the association between insufficient level of physical activity and multiple health risk behaviors (HRB) in adolescents. Methods: This is an epidemiological study with cross-sectional design carried out in 2016 with 3,617 adolescents aged
Lucas Souza Santos   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Simultaneity and “increased present” in the European Spanish perfect

open access: yesCatalan Journal of Linguistics, 2018
This paper deals with the concept of “simultaneity” in relation to the Spanish Present Perfect based on the descriptions made by Rojo (1974) and Rojo & Veiga (1999), and seeks to link it to other similar concepts proposed by other scholars, such as ...
Susana Azpiazu
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

On the conventional character of simultaneity in special relativity [PDF]

open access: yes, 2005
To be able to determine the simultaneity of distant events, one has to make use of a convention. Einstein's famous definition of simultaneity, which sets e=1/2 , is a case of such a convention.
Pabjan, Tadeusz
core  

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Children of time: the extended synthesis and major metaphors of evolution

open access: yesZoologia (Curitiba), 2012
It is time for an expansion and enrichment of evolutionary theory. The "back to the future" proposal contained herein is based on three postulates: 1) Neo-Darwinism is too impoverished for this task; 2) its predecessor, Darwinism, contained the necessary
Daniel R. Brooks, Salvatore J. Agosta
doaj  

Simultaneity and non-simultaneity taxis in the German language: temporal and aspectual factors (parametric model) [PDF]

open access: yesАктуальные проблемы филологии и педагогической лингвистики
This article, using the digital linguistic paradigm, examines the temporal and aspectual factors that determine the expression of the taxis relations of simultaneity and multitemporality in modern German.
Irina V. Arkhipova
doaj   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

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