Results 51 to 60 of about 6,395,940 (332)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Transverse Wave Propagation in Relativistic Two-fluid Plasmas in de Sitter Space

, 2008
We investigate transverse electromagnetic waves propagating in a plasma in the de Sitter space. Using the 3+1 formalism we derive the relativistic two-fluid equations to take account of the effects due to the horizon and describe the set of simultaneous ...
A. Strominger, A. Strominger, A.G. Reiss, A.H. Guth, B. Schmidt, C.G. Tsagas, C.G. Tsagas, C.G. Tsagas, C.G. Tsagas, C.M. Hull, C.M. Hull, C.P. Dettman, D. Papadopoulos, D.A. Macdonald, E. Harris, F. Jüttner, J. Bernstein, J. Daniel, J. Sakai, J.P. Ostriker, K. Kleidis, K. Kleidis, K. Subramanian, K.A. Holcomb, K.A. Holcomb, K.S. Thorne, K.S. Thorne, M. Atiqur Rahman, M. Forsberg, M. Hossain Ali, M. Marklund, M. Marklund, M. Servin, N. Bahcall, P.O. Mazur, R. Narayan, R.H. Price, S. Perlmutter, S. Perlmutter, T. Vachaspati, V. Buzzi, V. Buzzi, X.-H. Zhang, X.-H. Zhang   +43 more
core   +1 more source

Geodesic continued fractions and LLL [PDF]

, 2013
We discuss a proposal for a continued fraction-like algorithm to determine simultaneous rational approximations to $d$ real numbers $\alpha_1,\ldots,\alpha_d$. It combines an algorithm of Hermite and Lagarias with ideas from LLL-reduction. We dynamically
Beukers, Frits
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

ANALYSIS OF FACTORS INFLUENCING RICE IMPORTS IN INDONESIA AND THE IMPACT ON PRICE STABILITY [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences
The agricultural sector is one of the crucial sectors in human life. This sector significantly contributes to achieving the second Sustainable Development Goal (SDG), which aims for zero hunger, achieving food security, improving nutrition, and promoting
Hamimiy W., Bahri T.S., Hamid A.H.
doaj  

The Indirect Effect of Democracy on Economic Growth in the MENA Region (1990–2015)

Economies, 2018
This paper examines the indirect effect of democracy on economic growth using a dataset of 17 MENA countries from 1990 to 2015. Democracy is assumed to affect growth through a series of channels: education, health, physical capital accumulation per labor,
Shereen Nosier, Aya El-Karamani
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source